Goniodysgenesis in familial primary open-angle glaucoma
| العنوان: | Goniodysgenesis in familial primary open-angle glaucoma |
|---|---|
| المؤلفون: | W.v.d. Berg, J. W. Delleman, E. L. Greve, F. D. Verbraak |
| المساهمون: | Other departments |
| المصدر: | Acta ophthalmologica, 72(1), 98-102. Copenhagen Scriptor |
| بيانات النشر: | Wiley, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, genetic structures, Open angle glaucoma, Anterior Chamber, business.industry, Significant difference, Gonioscopy, Normal population, Glaucoma, Pilot Projects, General Medicine, Middle Aged, medicine.disease, eye diseases, Ophthalmology, Goniodysgenesis, Humans, Medicine, sense organs, business, Glaucoma, Open-Angle, Intraocular Pressure, High tension |
| الوصف: | Results of a pilot study to evaluate goniodysge-nesis as a cause of familial open-angle glaucoma are reported. Patients with a familial high tension open-angle glaucoma and a goniodysgenetic chamber angle (n = 11), a number of their relatives with glaucoma (n = 12), and their relatives without glaucoma (n = 26) were compared to a group of normals (n = 120). Eight characteristics of gonio-dysgenesis were scored and summed into a total gonio-dysgenesis-score for each chamber angle examined, a higher score corresponding to a more dysgenetic chamber angle. The distribution of the goniodysgenesis-score was compared between the four groups studied. A highly significant difference (p < 0.001) was found between the prob-ands and the normal population, but there was no difference in distribution between the relatives with glaucoma and the relatives without glaucoma. It is concluded that goniodysgenesis cannot explain the occurrence of glaucoma in the families investigated in this study. A significant difference was also found between the normal population and all the relatives combined, with higher scores in the group of relatives. An explanation could be that goniodysgenesis is inherited within the families studied, possibly in an autosomal dominant way, but independent of the occurrence of glaucoma. |
| تدمد: | 1755-375X 0001-639X |
| DOI: | 10.1111/j.1755-3768.1994.tb02745.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7280d42797bcc622be63d01cfa4002a5 https://doi.org/10.1111/j.1755-3768.1994.tb02745.x |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....7280d42797bcc622be63d01cfa4002a5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1755375X 0001639X |
|---|---|
| DOI: | 10.1111/j.1755-3768.1994.tb02745.x |