Genome-wide copy number profiling using a 100K SNP array reveals novel disease-related genes BORIS and TSHZ1 in juvenile angiofibroma
| العنوان: | Genome-wide copy number profiling using a 100K SNP array reveals novel disease-related genes BORIS and TSHZ1 in juvenile angiofibroma |
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| المؤلفون: | Vivienne Willnecker, Julia Dlugaiczyk, Piero Nicolai, Christian Thiel, Anita Rauch, Henryk Siwiec, Silke Wemmert, Bernhard Schick, Olaf Wendler |
| المصدر: | International Journal of Oncology. |
| بيانات النشر: | Spandidos Publications, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Cancer Research, DNA Copy Number Variations, Microarray, Nose Neoplasms, Intracellular Space, Genome-wide association study, Single-nucleotide polymorphism, Biology, Angiofibroma, Polymorphism, Single Nucleotide, Humans, SNP, RNA, Messenger, Epigenetics, Gene, Oligonucleotide Array Sequence Analysis, Chromosome Aberrations, Homeodomain Proteins, Genetics, Teashirt zinc finger homeobox 1, Molecular biology, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Repressor Proteins, Protein Transport, Oncology, Genome-Wide Association Study, SNP array |
| الوصف: | Juvenile angiofibroma (JA) is a unique fibrovascular tumor, which is almost exclusively found in the posterior nasal cavity of adolescent males. Although histologically classified as benign, the tumor often shows an aggressive growth pattern and has been associated with chromosomal imbalances, amplification of oncogenes and epigenetic dysregulation. We present the first genome-wide profiling of JAs (n=14) with a 100K single nucleotide polymorphism (SNP) microarray. Among the 30 novel JA-specific amplifications detected on autosomal chromosomes with this technique, the genes encoding the cancer-testis antigen BORIS (brother of the regulator of imprinted sites) and the developmental regulator protein TSHZ1 (teashirt zinc finger homeobox 1) were selected for further analysis. Gains for both BORIS (20q13.3) and TSHZ1 (18q22.3) were confirmed by quantitative genomic PCR. Furthermore, quantitative RT-PCR revealed a significant up-regulation of BORIS (p |
| تدمد: | 1791-2423 1019-6439 |
| DOI: | 10.3892/ijo.2011.1166 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7274e70967f146e24f6eecd52e27360e https://doi.org/10.3892/ijo.2011.1166 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7274e70967f146e24f6eecd52e27360e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17912423 10196439 |
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| DOI: | 10.3892/ijo.2011.1166 |