Graphene–Gold Nanostructures Hybrid Composites Screen-Printed Electrode for the Sensitive Electrochemical Detection of Vancomycin
| العنوان: | Graphene–Gold Nanostructures Hybrid Composites Screen-Printed Electrode for the Sensitive Electrochemical Detection of Vancomycin |
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| المؤلفون: | Ana-Maria Dragan, Alexandra Pusta, Adrian Blidar, Bogdan Feier, Cecilia Cristea |
| المصدر: | Coatings, Vol 9, Iss 10, p 652 (2019) Coatings Volume 9 Issue 10 |
| بيانات النشر: | MDPI AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Detection limit, Nanocomposite, Nanostructure, Materials science, medicine.drug_class, Graphene, vancomycin, graphene, Nanotechnology, Surfaces and Interfaces, Glycopeptide antibiotic, Surfaces, Coatings and Films, law.invention, gold nanostructures, Linear range, law, lcsh:TA1-2040, Electrode, Materials Chemistry, medicine, Vancomycin, antibiotic detection, lcsh:Engineering (General). Civil engineering (General), screen printed electrodes, medicine.drug |
| الوصف: | The most important and well-known glycopeptide antibiotic, vancomycin (VAN), is used for the treatment of severe bacterial infections like methicillin-resistant staphylococcal infections and endocarditis caused by enterococci and sepsis. Taking into account the problem of the development of antibiotic resistance as well as its toxicity, both correlated with the VAN concentration (CVAN) in biological samples, there is need for better and more accessible quantification methods for this antibiotic. Considering all of the above, herein, we present a simple electrochemical method for VAN sensing based on a hybrid graphene-gold nanostructure nanocomposite electrode, which allows double detection directly in the oxidation domain and also indirectly, in reduction, using the electro-active gold nanostructures as a probe to monitor the current changing due to the interaction between gold and VAN. The developed method was able to successfully detect VAN in the linear range of 1&ndash 100 µ M with a limit of detection (LOD) of 0.29 µ M for the direct approach and 0.5 µ M for the indirect one. The selectivity of the method was tested in the presence of other antibiotics and drugs. This method was successfully applied for the detection of VAN from human serum samples. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2079-6412 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72252e386bd772ec489b165498c2fbfa https://www.mdpi.com/2079-6412/9/10/652 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....72252e386bd772ec489b165498c2fbfa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20796412 |
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