Increased dosage of infliximab is a potential cause of Pneumocystis carinii pneumonia
| العنوان: | Increased dosage of infliximab is a potential cause of Pneumocystis carinii pneumonia |
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| المؤلفون: | Yoshiki Nomura, Shin Kashima, Junpei Sasajima, Takuya Iwama, Takuma Gotoh, Kazuyuki Tanaka, Katsuya Ikuta, Nobuhiro Ueno, Mikihiro Fujiya, Shugo Fujibayashi, Kentaro Moriichi, Aki Sakatani |
| المصدر: | Gut Pathogens |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | musculoskeletal diseases, medicine.medical_specialty, information science, Case Report, Disease, Microbiology, 03 medical and health sciences, 0302 clinical medicine, Medical microbiology, Virology, medicine, natural sciences, In patient, 030203 arthritis & rheumatology, business.industry, Gastroenterology, medicine.disease, Infliximab, respiratory tract diseases, Pneumonia, Infectious Diseases, Pneumocystis carinii, Immunology, 030211 gastroenterology & hepatology, Parasitology, Early phase, business, medicine.drug |
| الوصف: | http://creativecommons.org/licenses/by/4.0/ METHODS: Pneumocystis carinii pneumonia occasionally appears in immunodeficient patients. While several reports have shown that Pneumocystis carinii pneumonia occurred in the early phase of starting infliximab treatment in patients with Crohn's disease (CD), the present case suggests for the first time that an increased dosage of infliximab may also lead to pneumonia. RESULTS: A 51-year-old male had been taking 5 mg of infliximab for the treatment of CD for 10 years with no adverse events. Beginning in September 2013, the dose of infliximab had to be increased to 10 mg/kg because his status worsened. Thereafter, he complained of a fever and cough, and a CT scan revealed ground-glass opacities in the lower lobes of the bilateral lung with a crazy-paving pattern. Bronchoscopy detected swelling of the tracheal mucosa with obvious dilations of the vessels. A polymerase chain reaction using a bronchoalveolar lavage fluid sample detected specific sequences for Pneumocystis jirovecii; thus he was diagnosed with Pneumocystis carinii (jirovecii) pneumonia. After discontinuing infliximab and starting antibiotic treatment, his symptoms and CT findings were dramatically improved. CONCLUSIONS: The administration of an increased dosage of infliximab can cause Pneumocystis carinii pneumonia in CD patients |
| تدمد: | 1757-4749 |
| DOI: | 10.1186/s13099-016-0086-4 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7196ee5883847b55da7cf5844564a0dd https://doi.org/10.1186/s13099-016-0086-4 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7196ee5883847b55da7cf5844564a0dd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17574749 |
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| DOI: | 10.1186/s13099-016-0086-4 |