The relationship between ring-type dedicated breast PET and immune microenvironment in early breast cancer
| العنوان: | The relationship between ring-type dedicated breast PET and immune microenvironment in early breast cancer |
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| المؤلفون: | Akiko Emi, Keiko Kajitani, N. Goda, Koji Arihiro, Takayuki Kadoya, Noriyuki Shiroma, Morihito Okada, Norio Masumoto, Shinsuke Sasada |
| المصدر: | Breast Cancer Research and Treatment. 177:651-657 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Multivariate analysis, Immune microenvironment, Breast Neoplasms, chemical and pharmacologic phenomena, Standardized uptake value, 03 medical and health sciences, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Breast cancer, Fluorodeoxyglucose F18, Internal medicine, Biomarkers, Tumor, Tumor Microenvironment, medicine, Humans, Aged, Aged, 80 and over, Tumor microenvironment, medicine.diagnostic_test, Tumor-infiltrating lymphocytes, business.industry, Middle Aged, medicine.disease, 030104 developmental biology, Positron emission tomography, Positron-Emission Tomography, 030220 oncology & carcinogenesis, Ring type, Female, Neoplasm Grading, Tomography, X-Ray Computed, business |
| الوصف: | 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography (PET) is related to the biological parameters and prognosis of breast cancer. However, whether whole-body PET (WBPET) and dedicated breast PET (DbPET) can reflect the tumor microenvironment is unclear. This study investigated the relationship between stromal tumor-infiltrating lymphocytes (TILs) and maximum standardized uptake value (SUVmax) in WBPET and DbPET. A total of 125 invasive breast cancers underwent WBPET and ring-type DbPET and resected specimens were pathologically assessed. The impact of SUVmax on the tumor biological parameters and TILs was retrospectively evaluated. SUVmax was classified as high and low relative to the median values (WBPET-SUVmax: 2.2 and DbPET-SUVmax: 6.0). SUVmax correlated with tumor size, nuclear grade, Ki-67 labeling index, and TILs in both WBPET and DbPET (all p |
| تدمد: | 1573-7217 0167-6806 |
| DOI: | 10.1007/s10549-019-05339-0 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716548dc4e65c2bb3ea268d1f788ef96 https://doi.org/10.1007/s10549-019-05339-0 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....716548dc4e65c2bb3ea268d1f788ef96 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15737217 01676806 |
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| DOI: | 10.1007/s10549-019-05339-0 |