Association analysis of the NOD2 gene with susceptibility to graft-versus-host disease in a Japanese population
| العنوان: | Association analysis of the NOD2 gene with susceptibility to graft-versus-host disease in a Japanese population |
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| المؤلفون: | Yoshinobu Eishi, Keisei Kawa, Takakazu Kawase, Natsu Yamaguchi, Yusuke Nakamura, Makoto Onizuka, Kazutoshi Koike, Yasuo Morishima, Masamichi Hara, Keiko Yamazaki, Hideki Akiyama, Hiroki Amano, Shigetaka Asano, Tsuyoshi Tanabe, Jun Ishikawa, Koichi Matsuda, Mikiko Kobayashi-Miura, Arinobu Tojo, Takehiko Mori, Yasuyuki Fujita, Satoshi Takahashi, Takeyasu Kakamu |
| المصدر: | International Journal of Hematology. 93:771-778 |
| بيانات النشر: | Springer Science and Business Media LLC, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Genotype, Nod2 Signaling Adaptor Protein, Graft vs Host Disease, Single-nucleotide polymorphism, Biology, Polymorphism, Single Nucleotide, Crohn Disease, Japan, NOD2, medicine, Humans, Genetic Predisposition to Disease, Alleles, Leukemia, Donor selection, Hematology, Odds ratio, medicine.disease, digestive system diseases, HEK293 Cells, medicine.anatomical_structure, Graft-versus-host disease, Gene Expression Regulation, Immunology, Cytokine secretion, Bone marrow |
| الوصف: | Members of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family participate in the innate immune system, exerting widespread effects on cytokine secretion, autophagy, and apoptosis. Recent studies in Caucasians revealed the association between mutants of NOD2, a member of the NLR family, and severity of acute graft-versus-host disease (GVHD). NOD2 polymorphism screening has been recommended for donor selection and risk assessment at bone marrow transplantation. To investigate whether NOD2 plays a role in the pathogenesis of GVHD in a Japanese population, we examined DNA from 142 bone marrow transplant patient/donor pairs to detect genetic variation in the NOD2 gene. No genetic variants of NOD2 were associated with the severity of acute GVHD in our patients. However, a weak association between a single nucleotide polymorphism in the NOD2 gene (R471C) and acute myeloid leukemia in the bone marrow patients (p = 0.029, odds ratio 4.08, 95% CI 1.22-13.67) was detected. This polymorphism was not prevalent in 479 Crohn's disease (CD) patients in Japan. These results suggest that, in the Japanese population, unlike the Caucasian, NOD2 is not a major contributor to susceptibility to severe acute GVHD. |
| تدمد: | 1865-3774 0925-5710 |
| DOI: | 10.1007/s12185-011-0860-5 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7156be84d1e081a218031337829b3a7a https://doi.org/10.1007/s12185-011-0860-5 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....7156be84d1e081a218031337829b3a7a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18653774 09255710 |
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| DOI: | 10.1007/s12185-011-0860-5 |