Dynamics of Plasmatic Levels of Pro- and Anti-Inflammatory Cytokines in HIV-Infected Individuals with M. tuberculosis Co-Infection
| العنوان: | Dynamics of Plasmatic Levels of Pro- and Anti-Inflammatory Cytokines in HIV-Infected Individuals with M. tuberculosis Co-Infection |
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| المؤلفون: | Alexandr Sobkin, V. V. Pokrovsky, Oxana Svitich, Zverev Vv, Konstantin Ryzhov, Ulyana Kuimova, Marina Nosik, Irina Rymanova, Alexey Kravtchenko |
| المصدر: | Microorganisms, Vol 9, Iss 2291, p 2291 (2021) Microorganisms Volume 9 Issue 11 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Microbiology (medical), HIV/TB co-infection, Tuberculosis, business.industry, QH301-705.5, Incidence (epidemiology), virus diseases, HIV, Disease, cytokine profile, medicine.disease, Microbiology, immune reconstitution inflammatory syndrome, Pathogenesis, Immune system, Viral replication, Immune reconstitution inflammatory syndrome, tuberculosis, Virology, Cohort, Immunology, medicine, Biology (General), business, ART |
| الوصف: | Tuberculosis (TB) and HIV have profound effects on the immune system, which can lead to the activation of viral replication and negatively regulate the activation of T cells. Dysregulation in the production of cytokines necessary to fight HIV and M. tuberculosis may ultimately affect the results of the treatment and be important in the pathogenesis of HIV infection and TB. This work presents the results of a study of the expression of pro- and anti-inflammatory cytokines (IFN-γ, TNF-α, IL-2, IL-4, IL-6, IL-10, IL-1RA) in drug-naïve patients with dual infection of HIV/TB at the late stages of HIV-infection, with newly diagnosed HIV and TB, and previously untreated HIV in the process of receiving antiretroviral (ART) and TB treatment vs. a cohort of patients with HIV monoinfection and TB monoinfection. The study revealed that during a double HIV/TB infection, both Th1 and Th2 immune responses are suppressed, and a prolonged dysregulation of the immune response and an increased severity of the disease in pulmonary/extrapulmonary tuberculosis is observed in HIV/TB co-infection. Moreover, it was revealed that a double HIV/TB infection is characterized by delayed and incomplete recovery of immune activity. High levels of IL-6 were detected in patients with HIV/TB co-infection before initiation of dual therapy (2.1-fold increase vs. HIV), which persisted even after 6 months of treatment (8.96-fold increase vs. HIV), unlike other cytokines. The persistent enhanced expression of IL-6 in patients with dual HIV/TB co-infection allows the consideration of it as a potential marker of early detection of M. tuberculosis infection in HIV-infected individuals. The results of multivariate regression analysis showed a statistical trend towards an increase in the incidence of IRIS in patients with high IL-1Ra levels (in the range of 1550–2500 pg/mL): OR = 4.3 (95%CI 3.7–14.12, p = 0.53), which also allows IL-1Ra to be considered as a potential predictive biomarker of the development of TB-IRIS and treatment outcomes. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-2607 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fb91c19806c286ad9d4143352a812c https://www.mdpi.com/2076-2607/9/11/2291 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....70fb91c19806c286ad9d4143352a812c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20762607 |
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