Benzodiazepine and Z-Drug Use and the Risk of Developing Dementia
| العنوان: | Benzodiazepine and Z-Drug Use and the Risk of Developing Dementia |
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| المؤلفون: | Gerard Piñol-Ripoll, Eric Grill, Jordi de Batlle, Miquel Buti, Gaston Besanson, Leonardo Galván, Farida Dakterzada, Francisco Torres-Bondia, Roman Buil |
| المساهمون: | Universitat Oberta de Catalunya (UOC), Santa Maria University Hospital, Institut Català de la Salut |
| المصدر: | O2, repositorio institucional de la UOC Universitat Oberta de Catalunya (UOC) |
| بيانات النشر: | Oxford University Press (OUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Substance-Related Disorders, benzodiacepina, Cohort Studies, Benzodiazepines, Risk Factors, Internal medicine, medicine, Humans, Dementia, Pharmacology (medical), enfermetat de l'alzheimer, Cognitive decline, benzodiazepines, Aged, Retrospective Studies, benzodiacepinas, Pharmacology, business.industry, Incidence (epidemiology), Hazard ratio, Confounding, Z-drug, alzheimer’s disease, droga-z, Retrospective cohort study, cognitive decline, medicine.disease, enfermedad del alzheimer, Psychiatry and Mental health, Cohort, Female, benzodiazepine, business, deteriorament cognitiu, Cohort study |
| الوصف: | Background Benzodiazepines (BZDs) and Z-drugs (BZDRs) are among the most prescribed medications for anxiety and insomnia, especially among older adults. Our objective was to investigate the association between the use of BZDRs and the risk of dementia. Methods A community-based retrospective cohort study was conducted based on the data available from 2002 to 2015 in Catalan Health Service. This cohort included all BZDR users (N = 83 138) and nonusers (N = 84 652) older than 45 years. A minimum 5-year lag window and an adjustment for psychiatric problems were applied for the data analysis. Results The hazard ratio (HR) for the risk of incident dementia among BZDR users was 1.22 (95% CI = 1.15 to 1.31). This risk was not significant after adjusting the data confounding factors (HR = 1.01; 95% CI = 0.94 to 1.08). We observed a higher risk with short-to-intermediate half-life BZDs (HR = 1.11; 95% CI = 1.04 to 1.20) and Z-drugs (HR = 1.20; 95% CI = 1.07 to 1.33) than for intermediate-to-long half-life BZDs (HR = 1.01; 95% CI = 0.94 to 1.08). We demonstrated a higher risk of incident dementia (HR = 1.23; 95% CI = 1.07 to 1.41 and odds ratio = 1.38; 95% CI = 1.27 to 1.50, respectively) in patients who received 91 to 180 defined daily doses (DDDs) and >180 DDDs compared with patients who received Conclusion We found that the incidence of dementia was not higher among all BZDR users. Short half-life BZDs and Z-drugs increased the risk of dementia at the highest doses, especially in female patients, showing a dose-response relationship. |
| وصف الملف: | application/pdf |
| تدمد: | 1469-5111 1461-1457 |
| DOI: | 10.1093/ijnp/pyab073 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ba535944adaf6d7750b087cdc9cbd6 https://doi.org/10.1093/ijnp/pyab073 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....70ba535944adaf6d7750b087cdc9cbd6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14695111 14611457 |
|---|---|
| DOI: | 10.1093/ijnp/pyab073 |