An open-label, dose-escalation, safety, and pharmacokinetics phase I study of ombrabulin, a vascular disrupting agent, administered as a 30-min intravenous infusion every 3 weeks in Japanese patients with advanced solid tumors
| العنوان: | An open-label, dose-escalation, safety, and pharmacokinetics phase I study of ombrabulin, a vascular disrupting agent, administered as a 30-min intravenous infusion every 3 weeks in Japanese patients with advanced solid tumors |
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| المؤلفون: | Noboru Yamamoto, Haruyasu Murakami, Kaoru Tanaka, Toshiaki Takahashi, Kazuhiko Nakagawa, Hidetoshi Hayashi, Junichiro Watanabe, Hidemi Kiyota, Akira Ono, Yasuhito Fujisaka, Takayasu Kurata, Yusuke Onozawa, S. Kuroda |
| المصدر: | Cancer Chemotherapy and Pharmacology |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, Cancer Research, Maximum Tolerated Dose, Ombrabulin, Pharmacokinetic, Pharmacology, Toxicology, Drug Administration Schedule, Cohort Studies, chemistry.chemical_compound, Phase I, Asian People, Pharmacokinetics, Neoplasms, Vascular disrupting agent, Serine, Dose escalation, Humans, Medicine, Pharmacology (medical), Infusions, Intravenous, Antitumor activity, Dose-Response Relationship, Drug, Neovascularization, Pathologic, business.industry, Middle Aged, Phase i study, Clinical trial, Japanese patients, Oncology, chemistry, Maximum tolerated dose, Female, Original Article, Open label, business |
| الوصف: | Purpose To determine ombrabulin’s maximum tolerated dose and dose recommended for Japanese patients with advanced solid tumors and to assess its antitumor activity and overall safety and pharmacokinetic profiles. Methods This was a multi-center, open-label, sequential-cohort, dose-escalation phase I study of ombrabulin, a vascular disrupting agent, administered once every 3 weeks. Patients were treated with 15.5, 25, 35, or 50 mg/m2 ombrabulin over a 30-min intravenous infusion. The recommended dose was the highest dose at which |
| تدمد: | 1432-0843 0344-5704 |
| DOI: | 10.1007/s00280-014-2388-x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a3944b060588903a928249b79f13f6 https://doi.org/10.1007/s00280-014-2388-x |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....70a3944b060588903a928249b79f13f6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320843 03445704 |
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| DOI: | 10.1007/s00280-014-2388-x |