التفاصيل البيبلوغرافية
| العنوان: |
PBRM1 regulates the stress response in epithelial cells |
| المؤلفون: |
Majid Kazemian, Elizabeth G. Porter, Michael K. Wendt, Benjamin Carter, Jane C. Stewart, Hang Lin, Basudev Chowdhury, Alisha Dhiman, Emily C. Dykhuizen |
| بيانات النشر: |
Cold Spring Harbor Laboratory, 2018. |
| سنة النشر: |
2018 |
| مصطلحات موضوعية: |
0303 health sciences, Cell growth, Chemistry, Protein subunit, Epithelium, Bromodomain, PBRM1, Chromatin, Cell biology, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Apoptosis, 030220 oncology & carcinogenesis, medicine, Gene, 030304 developmental biology |
| الوصف: |
SummaryPolybromo1 (PBRM1) is a chromatin remodeler subunit highly mutated in cancer, particularly renal clear cell carcinoma. PBRM1 is a member of the SWI/SNF subcomplex, PBAF (PBRM1-Brg1/Brm Associated Factors) and is characterized by six tandem bromodomains. Here we establish a role for PBRM1 in epithelial cell maintenance through the expression of genes involved in cell adhesion, metabolism, stress response, and apoptosis. In support of a general role for PBRM1 in stress response and apoptosis, we observe that loss of PBRM1 results in an increase in reactive oxygen species generation and a decrease in cellular viability under stress conditions. We find that loss of PBRM1 promotes cell growth under favorable conditions but is required for cell survival under conditions of cellular stress. |
| اللغة: |
English |
| DOI: |
10.1101/408575 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70941fa2c5c2358725e428df61a825ee |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....70941fa2c5c2358725e428df61a825ee |
| قاعدة البيانات: |
OpenAIRE |