Redox regulation of tyrosine kinase signalling: more than meets the eye
| العنوان: | Redox regulation of tyrosine kinase signalling: more than meets the eye |
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| المؤلفون: | Miao-Chong J. Lin, Christopher M. Dustin, Albert van der Vliet, David E. Heppner |
| المصدر: | J Biochem |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0303 health sciences, biology, Chemistry, Kinase, Phosphatase, General Medicine, Protein-Tyrosine Kinases, Biochemistry, Hedgehog signaling pathway, Cell biology, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, biology.protein, Humans, JB Special Issue – Reviews, Epidermal growth factor receptor, Tyrosine, Signal transduction, Oxidation-Reduction, Molecular Biology, Tyrosine kinase, Signal Transduction, 030304 developmental biology, Proto-oncogene tyrosine-protein kinase Src |
| الوصف: | Protein kinases are essential mediators of cellular signal transduction and are often dysregulated in disease. Among these, protein tyrosine kinases (PTKs) have received specific interest due to their common roles in various diseases including cancer, and emerging observations indicating that PTK signalling pathways are susceptible to regulation by reactive oxygen species (ROS), which are also frequently implicated in disease pathology. While it is well recognized that ROS can impact on tyrosine kinase signalling by inhibiting tyrosine phosphatases, more recent studies highlight additional modes of redox-based regulation of tyrosine kinase signalling by direct redox modification of non-catalytic cysteines within tyrosine kinases or other protein components of this signalling pathway. In this review, we will present recent advancements with respect to redox-based mechanisms in regulating PTK signalling, with a specific focus on recent studies demonstrating direct redox regulation of Src-family kinases and epidermal growth factor receptor kinases. Importantly, redox-based modulation of tyrosine kinases may be relevant for many other kinases and has implications for current approaches to develop pharmacological inhibitors for these proteins. |
| تدمد: | 1756-2651 0021-924X |
| DOI: | 10.1093/jb/mvz085 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706e07eac2beb0d20c1b9c4081a891f7 https://doi.org/10.1093/jb/mvz085 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....706e07eac2beb0d20c1b9c4081a891f7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17562651 0021924X |
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| DOI: | 10.1093/jb/mvz085 |