Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies
| العنوان: | Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies |
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| المؤلفون: | Gil Atzmon, Rosalind Ramsey-Goldman, Barry J. McDonnell, Yun-Ling Zheng, David Gilley, Teresa E. Seeman, Maciej Tomaszewski, Massimo Mangino, Geja J. Hageman, Florian Kronenberg, Iiris Hovatta, Giuseppe Paolisso, Line Rode, Ellen W. Demerath, Jaakko Kaprio, Katarina Nordfjäll, Jonathan N. Hofmann, Peter Willeit, Rosana Maria dos Reis, Barbara Kollerits, Andrea Elena Iglesias Molli, Guo Cheng, Wei Zheng, Karen A. Mather, Daniel Eisenberg, Fadi J. Charchar, Sarah E. Harris, Bianca D’Antono, Jason Y.Y. Wong, Sofia Pavanello, Lisa A. Boardman, Guillaume Paré, Jacob B. H. Hjelmborg, Erik J. Giltay, Tim De Meyer, Evangelia Antoniou, Dmytro Krasnienkov, Maurice P. Zeegers, Marek Kasielski, Audrey E. Hendricks, Linda Broer, Lifang Hou, Andrew Steptoe, Andrew J. Pellatt, Jennifer A. Nettleton, Vanessa A. Diaz, Steven C. Hunt, Marij Gielen, Josine E. Verhoeven, Christian Gieger, Roxanne Schaakxs, Belinda L. Needham, Catherine Duggan, Timo E. Strandberg, Ute Mons, Klelia D. Salpea, Jeremy D. Kark, Raffaela Zannolli, Muthuswamy Balasubramanyam, Michael Chong, Richard P. Ebstein, Daniel Bunout, Amelia Marti, Kristina Sundquist, Lisa Mirabello, Hisham Nassar, David J. Kurz, Ramin Farzaneh-Far, Ilja Demuth, Pim van der Harst |
| المساهمون: | Gielen, Marij, Hageman, Geja J., Antoniou, Evangelia E., Nordfjall, Katarina, Mangino, Massimo, Balasubramanyam, Muthuswamy, De Meyer, Tim, Hendricks, Audrey E., Giltay, Erik J., Hunt, Steven C., Nettleton, Jennifer A., Salpea, Klelia D., Diaz, Vanessa A., Farzaneh-Far, Ramin, Atzmon, Gil, Harris, Sarah E., Hou, Lifang, Gilley, David, Hovatta, Iiri, Kark, Jeremy D., Nassar, Hisham, Kurz, David J., Mather, Karen A., Willeit, Peter, Zheng, Yun-Ling, Pavanello, Sofia, Demerath, Ellen W., Rode, Line, Bunout, Daniel, Steptoe, Andrew, Boardman, Lisa, Marti, Amelia, Needham, Belinda, Zheng, Wei, Ramsey-Goldman, Rosalind, Pellatt, Andrew J., Kaprio, Jaakko, Hofmann, Jonathan N., Gieger, Christian, Paolisso, Giuseppe, Hjelmborg, Jacob B. H., Mirabello, Lisa, Seeman, Teresa, Wong, Jason, Van Der Harst, Pim, Broer, Linda, Kronenberg, Florian, Kollerits, Barbara, Strandberg, Timo, Eisenberg, Dan T. A., Duggan, Catherine, Verhoeven, Josine E., Schaakxs, Roxanne, Zannolli, Raffaela, Dos Reis, Rosana M. R., Charchar, Fadi J., Tomaszewski, Maciej, Mons, Ute, Demuth, Ilja, Molli, Andrea Elena Iglesia, Cheng, Guo, Krasnienkov, Dmytro, D'Antono, Bianca, Kasielski, Marek, Mcdonnell, Barry J., Ebstein, Richard Paul, Sundquist, Kristina, Pare, Guillaume, Chong, Michael, Zeegers, Maurice P., Complexe Genetica, RS: NUTRIM - R3 - Respiratory & Age-related Health, Farmacologie en Toxicologie, Section Eating Disorders and Obesity, RS: FPN CPS II, RS: CAPHRI - R5 - Optimising Patient Care, TELOMAAS Group, Internal Medicine, Psychiatry, APH - Mental Health, Cardiovascular Centre (CVC) |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Christensen, K & TELOMAAS group 2018, ' Body mass index is negatively associated with telomere length : A collaborative cross-sectional meta-analysis of 87 observational studies ', American Journal of Clinical Nutrition, vol. 108, no. 3, pp. 453-475 . https://doi.org/10.1093/ajcn/nqy107 American Journal of Clinical Nutrition, 108(3), 453-475 Gielen, M, Hageman, G J, Antoniou, E E, Nordfjall, K, Mangino, M, Balasubramanyam, M, De Meyer, T, Hendricks, A E, Giltay, E J, Hunt, S C, Nettleton, J A, Salpea, K D, Diaz, V A, Farzaneh-far, R, Atzmon, G, Harris, S E, Hou, L, Gilley, D, Hovatta, I, Kark, J D, Nassar, H, Kurz, D J, Mather, K A, Willeit, P, Zheng, Y, Pavanello, S, Demerath, E W, Rode, L, Bunout, D, Steptoe, A, Boardman, L, Marti, A, Needham, B, Zheng, W, Ramsey-goldman, R, Pellatt, A J, Kaprio, J, Hofmann, J N, Gieger, C, Paolisso, G, Hjelmborg, J B H, Mirabello, L, Seeman, T, Wong, J, Van Der Harst, P, Broer, L, Kronenberg, F, Kollerits, B, Strandberg, T, Eisenberg, D T A, Duggan, C, Verhoeven, J E, Schaakxs, R, Zannolli, R, Dos Reis, R M R, Charchar, F J, Tomaszewski, M, Mons, U, Demuth, I, Molli, A E I, Cheng, G, Krasnienkov, D, D'antono, B, Kasielski, M, Mcdonnell, B J, Ebstein, R P, Sundquist, K, Pare, G, Chong, M & Zeegers, M P 2018, ' Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies ', The American journal of clinical nutrition, vol. 108, no. 3, pp. 453-475 . https://doi.org/10.1093/ajcn/nqy107 TELOMAAS group 2018, ' Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis of 87 observational studies ', American Journal of Clinical Nutrition, vol. 108, no. 3, pp. 453-475 . https://doi.org/10.1093/ajcn/nqy107 American Journal of Clinical Nutrition, 108(3), 453-475. Oxford University Press American Journal of Clinical Nutrition The American Journal of Clinical Nutrition American Journal of Clinical Nutrition, 108(3), 453-475. American Society for Nutrition |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, obesity, Cross-sectional study, Medicine (miscellaneous), BMI, Low-grade inflammation, Meta-analysis, Obesity, Observational studies, Telomere length, Nutrition and Dietetics, 030204 cardiovascular system & hematology, Body Mass Index, 0302 clinical medicine, Ethnicity, Leukocytes, telomere length, low-grade inflammation, Young adult, Telomere Shortening, 2. Zero hunger, Aged, 80 and over, education.field_of_study, INSULIN-RESISTANCE, Age Factors, Middle Aged, Telomere, OXIDATIVE DNA-DAMAGE, Original Research Communications, CARDIOVASCULAR-DISEASE, STRONG HEART FAMILY, CORONARY-ARTERY CALCIFICATION, Adult, Adolescent, Population, INFLAMAÇÃO, 03 medical and health sciences, Insulin resistance, Sex Factors, Linear regression, medicine, Humans, Meta-analysi, education, observational studies, Aged, CANCER RISK, business.industry, II BASE-II, medicine.disease, Observational studie, AMERICAN-INDIANS, meta-analysis, 030104 developmental biology, Cross-Sectional Studies, PULSE-WAVE VELOCITY, HELSINKI BIRTH COHORT, business, Body mass index, Demography |
| الوصف: | Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to accelerated shortening of telomeres. Consequently, obese persons are more likely to have shorter telomeres, but the association between body mass index (BMI) and leukocyte telomere length (TL) might differ across the life span and between ethnicities and sexes. Objective: A collaborative cross-sectionalmeta-analysis of observational studies was conducted to investigate the associations between BMI and TL across the life span. Design: Eighty-seven distinct study samples were included in the meta-analysis capturing data from 146,114 individuals. Studyspecific age- and sex-adjusted regression coefficients were combined by using a random-effects model in which absolute [base pairs (bp)] and relative telomere to single-copy gene ratio (T/S ratio) TLs were regressed against BMI. Stratified analysis was performed by 3 age categories ("young": 18-60 y; "middle": 61-75 y; and "old": >75 y), sex, and ethnicity. Results: Each unit increase in BMI corresponded to a-3.99 bp (95% CI: -5.17, -2.81 bp) difference in TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -7.67 bp (95% CI:-10.03,-5.31 bp) difference. Each unit increase in BMI corresponded to a -1.58 × 10-3 unit T/S ratio (0.16% decrease; 95% CI: -2.14 × 10-3, -1.01 × 10-3) difference in ageand sex-adjusted relative TL in the total pooled sample; among young adults, each unit increase in BMI corresponded to a -2.58 × 10-3 unit T/S ratio (0.26% decrease; 95% CI: -3.92 × 10-3, -1.25 × 10-3). The associations were predominantly for the white pooled population. No sex differences were observed. Conclusions: A higher BMI is associated with shorter telomeres, especially in younger individuals. The presently observed difference is not negligible. Meta-analyses of longitudinal studies evaluating change in body weight alongside change in TL arewarranted. |
| وصف الملف: | application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/pdf |
| اللغة: | English |
| تدمد: | 0002-9165 |
| DOI: | 10.1093/ajcn/nqy107 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdf732c38593d0bc118ec9a93d2b12d https://hdl.handle.net/1887/96085 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6fdf732c38593d0bc118ec9a93d2b12d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00029165 |
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| DOI: | 10.1093/ajcn/nqy107 |