Post-treatment changes of tumour perfusion parameters can help to predict survival in patients with high-grade astrocytoma
| العنوان: | Post-treatment changes of tumour perfusion parameters can help to predict survival in patients with high-grade astrocytoma |
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| المؤلفون: | Antonio Revert-Ventura, Fares Salamé-Gamarra, Alexandre Perez-Girbes, Roberto Sanz-Requena, Gracián García-Martí, Enrique Mollà-Olmos, Luis Martí-Bonmatí |
| المصدر: | European Radiology. 27:3392-3400 |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Kaplan-Meier Estimate, Astrocytoma, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Tumour perfusion, Overall survival, medicine, Humans, Radiology, Nuclear Medicine and imaging, In patient, Aged, Retrospective Studies, Neuroradiology, Neovascularization, Pathologic, medicine.diagnostic_test, Brain Neoplasms, business.industry, Interventional radiology, General Medicine, Middle Aged, Prognosis, medicine.disease, Combined Modality Therapy, Magnetic Resonance Imaging, Perfusion, Cerebrovascular Circulation, Female, sense organs, Radiology, Neoplasm Grading, Post treatment, business, 030217 neurology & neurosurgery |
| الوصف: | Vascular characteristics of tumour and peritumoral volumes of high-grade gliomas change with treatment. This work evaluates the variations of T2*-weighted perfusion parameters as overall survival (OS) predictors.Forty-five patients with histologically confirmed high-grade astrocytoma (8 grade III and 37 grade IV) were included. All patients underwent pre- and post-treatment T2*-weighted contrast-enhanced magnetic resonance (MR) imaging. Tumour, peritumoral and control volumes were segmented. Relative variations of cerebral blood flow (CBF), cerebral blood volume (CBV), mean transit time (MTT), KFor the tumour region, the 90th percentile increase or stagnation of CBV was associated with shorter survival, while a decrease related to longer survival (393 ± 189 vs 594 ± 294 days; log-rank p = 0.019; Cox hazard-ratio, 2.31; 95% confidence interval [CI], 1.12-4.74). KPost-treatment variations of the highest CBV and K• Vascular characteristics of high-grade glioma tumour and peritumoral regions change with treatment. • Quantitative assessment of MRI perfusion provides valuable information regarding tumour aggressiveness. • Quantitative T2*-weighted perfusion parameters can help to predict overall survival. • Post-treatment variations of CBV and K |
| تدمد: | 1432-1084 0938-7994 |
| DOI: | 10.1007/s00330-016-4699-2 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f6ebe6625ddba0c17644d447b16bdd9 https://doi.org/10.1007/s00330-016-4699-2 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....6f6ebe6625ddba0c17644d447b16bdd9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321084 09387994 |
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| DOI: | 10.1007/s00330-016-4699-2 |