Pyroprocess technology has been considered as a fuel cycle option to solve the spent fuel accumulation problems in Korea. The Korea Atomic Energy Research Institute, Daejeon, Korea has been studying pyroprocess technology, and the conceptual design of an engineering-scale pyroprocess facility, called the Reference Engineering-scale Pyroprocess Facility, has been performed on the basis of a 10 ton heavy metal throughput per year. In this paper the concept of Reference Engineering-scale Pyroprocess Facility is introduced along with its safety requirements for the protection of facility workers, collocated workers, the off-site public, and the environment. For the identification of safety structures, systems, and components and/or administrative controls, the following activities were conducted: (1) identifying hazards associated with operations; (2) identifying potential events associated with these hazards; and (3) identifying the potential preventive and/or mitigative controls that reduce the risk associated with these accident events. This study will be used to perform a safety evaluation for accidents involving any of the hazards identified, and to establish safety design policies and propose a more definite safety design.