Correlation Between SNOT-22, Nasal Cytology, and Mood Disorders in Patients With Allergic Rhinitis Treated With a Liposomal Nasal Spray
| العنوان: | Correlation Between SNOT-22, Nasal Cytology, and Mood Disorders in Patients With Allergic Rhinitis Treated With a Liposomal Nasal Spray |
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| المؤلفون: | Stefano Necozione, Alberto Eibenstein, Cinzia Tucci, Marina Pasqua, Maria Lauriello, Gian-Piero di Marco, Gaia Sinatti, Vittoria Di Rubbo |
| المصدر: | Allergy & Rhinology Allergy & Rhinology, Vol 10 (2019) |
| بيانات النشر: | SAGE Publications, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, liposomes, medicine.medical_specialty, Visual analogue scale, medicine.medical_treatment, Mucous membrane of nose, Sino-Nasal Outcome Test-22, mood disorder, Hospital Anxiety and Depression Scale, Gastroenterology, nasal cytology, Correlation, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Cytology, otorhinolaryngologic diseases, Immunology and Allergy, Medicine, 030223 otorhinolaryngology, Original Research, allergic rhinitis, HADS test, business.industry, respiratory system, medicine.disease, lcsh:Otorhinolaryngology, lcsh:RF1-547, 030228 respiratory system, Otorhinolaryngology, Nasal spray, Mood disorders, Anxiety, medicine.symptom, business, lcsh:RC581-607 |
| الوصف: | Patients with allergic rhinitis (AR) can suffer from mood disorders. The aim of this study was to investigate the clinical effect of a liposomal nasal spray (LN) containing vitamins A and E on the nasal mucosa in patients suffering from AR who had refused any type of anti-allergic treatment. For this purpose, the results of nasal cytology, Visual Analog Scale (VAS), Sino-Nasal Outcome Test-22 (SNOT-22), and Hospital Anxiety and Depression Scale (HADS) test were analyzed. Moreover, we evaluated the relationship between SNOT-22 and nasal cytology and between nasal symptoms and HADS scores. Statistical analysis revealed a significant decrease of scores at T1 in the LN treatment group as concerns VAS, SNOT-22, HADS-Anxiety test and a remarkable reduction of inflammatory cells detected with nasal cytology. Our study showed that higher levels of SNOT-22 corresponded to a higher level of HADS-Anxiety. The mechanisms underlying this relationship in AR patients are currently unknown, but we can suppose that improving mucosal trophism may contribute to the decrease of nasal symptoms and anxiety scores. The improvement of nasal symptoms, as measured by SNOT-22, was significantly correlated with the objective results of nasal cytology. These relationships between SNOT-22 and nasal cytology and between anxiety and cytology were investigated for the first time in our research. |
| اللغة: | English |
| تدمد: | 2152-6567 2152-6575 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ead502bd5cdf917346d6429c336978e http://europepmc.org/articles/PMC6676260 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6ead502bd5cdf917346d6429c336978e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21526567 21526575 |
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