A Partially Hydrolyzed Whey Infant Formula Supports Appropriate Growth: A Randomized Controlled Non-Inferiority Trial
| العنوان: | A Partially Hydrolyzed Whey Infant Formula Supports Appropriate Growth: A Randomized Controlled Non-Inferiority Trial |
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| المؤلفون: | Yannis Manios, Alexandros Sakellariou, Giorgos Zervas, Georgios Babilis, Tarek-Michail Kampani, Eva Karaglani, Christina Chairistanidou, Christina Filoilia, Inge Thijs-Verhoeven, Maria Matiatou, Stavroula Valaveri, Rolf Bos, Vasileios Miligkos, Marjan Gros |
| المصدر: | Nutrients Volume 12 Issue 10 Nutrients, Vol 12, Iss 3056, p 3056 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Time Factors, growth, lcsh:TX341-641, Weight Gain, Article, law.invention, Body Mass Index, 03 medical and health sciences, Eating, 0302 clinical medicine, Child Development, Randomized controlled trial, Double-Blind Method, Standard infant formula, law, 030225 pediatrics, Internal medicine, Whey, partially hydrolyzed formula, medicine, Body Size, Humans, Infant Nutritional Physiological Phenomena, Nutrition and Dietetics, anthropometry, business.industry, Hydrolysis, Age Factors, Infant, infant formula, Anthropometry, Confidence interval, Healthy Volunteers, Infant formula, Non inferiority trial, 030211 gastroenterology & hepatology, Female, medicine.symptom, business, lcsh:Nutrition. Foods and food supply, Weight gain, Body mass index, Food Science, protein hydrolysate |
| الوصف: | The aim of the current study was to investigate the effects of a partially hydrolyzed whey infant formula (PHF) on growth in healthy term infants as compared to a standard infant formula with intact protein (IPF). In a double-blind, non-inferiority, randomized controlled trial, a total of 163 healthy formula-fed infants, 55&ndash 80 days old, were recruited and randomly allocated to either the PHF (test) or the IPF (control) group. They were followed up for three months during which they were evaluated monthly on growth and development. In total, 21 infants discontinued the study, while 142 infants completed the study (test n = 72, control n = 70). The primary outcome was daily weight gain during the three months. Secondary outcomes included additional anthropometric indices at every timepoint over the intervention period. Daily weight gain during the three-month intervention period was similar in both groups with the lower bound of 95% confidence interval (CI) above the non-inferiority margin of &minus 3 g/day [mean difference (95% CI) test vs. control: &minus 0.474 (&minus 2.460, 1.512) g/day]. Regarding secondary outcomes, i.e., infants&rsquo weight, length, head circumference, body mass index (BMI), and their Z-scores, no differences were observed between the two groups at any time point. The PHF resulted in similar infant growth outcomes as the standard IPF. Based on these results, it can be concluded that the partially hydrolyzed whey infant formula supports adequate growth in healthy term infants. |
| وصف الملف: | application/pdf |
| تدمد: | 2072-6643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e4a23f1770ae259283704061a97b907 https://pubmed.ncbi.nlm.nih.gov/33036201 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6e4a23f1770ae259283704061a97b907 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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