Potential Therapeutic Role of Cationic Peptides in Three Experimental Models of Septic Shock
| العنوان: | Potential Therapeutic Role of Cationic Peptides in Three Experimental Models of Septic Shock |
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| المؤلفون: | Maria Simona Del Prete, Roberto Ghiselli, Wojciech Kamysz, Federico Mocchegiani, Oscar Cirioni, Elzbieta Łempicka, C. Viticchi, Vittorio Saba, Andrea Giacometti, Giorgio Scalise |
| المصدر: | Antimicrobial Agents and Chemotherapy. 46:2132-2136 |
| بيانات النشر: | American Society for Microbiology, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | Male, Imipenem, Lipopolysaccharide, medicine.medical_treatment, Intraperitoneal injection, Microbial Sensitivity Tests, Biology, Pharmacology, Microbiology, Sepsis, chemistry.chemical_compound, Anti-Infective Agents, medicine, Animals, Experimental Therapeutics, Pharmacology (medical), Rats, Wistar, Saline, Antibacterial agent, Tumor Necrosis Factor-alpha, Septic shock, Proteins, medicine.disease, Shock, Septic, Rats, Endotoxins, Disease Models, Animal, Infectious Diseases, chemistry, Indolicidin, Antimicrobial Cationic Peptides, medicine.drug |
| الوصف: | The therapeutic efficacies of buforin II, indolicidin, and KFFKFFKFF were investigated in three rat models of septic shock: (i) rats injected intraperitoneally with 10 μg ofEscherichia coliO111:B4 lipopolysaccharide, (ii) rats given an intraperitoneal injection of 2 × 1010CFU ofEscherichia coliATCC 25922, and (iii) rats in which intra-abdominal sepsis was induced via cecal ligation and single puncture. All animals were randomized to receive parenterally isotonic sodium chloride solution, 1 mg of buforin II per kg of body weight, 1 mg of indolicidin per kg, 1 mg of KFFKFFKFF per kg, and 20 mg of imipenem per kg. The main outcome measures were bacterial growth in abdominal exudate and plasma, endotoxin and tumor necrosis factor alpha (TNF-α) concentrations in plasma, and lethality. Treatment with all peptides resulted in significant reductions in plasma endotoxin and TNF-α concentrations compared with those resulting from the imipenem and saline treatments. On the other hand, imipenem treatment significantly reduced the levels of bacterial growth compared with the reductions achieved with the peptide and saline treatments. All compounds reduced the rates of death compared to that for the controls. Although the peptides demonstrated lower levels of antimicrobial activity than imipenem, they exhibited the dual properties of antimicrobial and antiendotoxin agents. |
| تدمد: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.46.7.2132-2136.2002 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6df382e7274de87c5dc285b6901db3bb https://doi.org/10.1128/aac.46.7.2132-2136.2002 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6df382e7274de87c5dc285b6901db3bb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10986596 00664804 |
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| DOI: | 10.1128/aac.46.7.2132-2136.2002 |