Influence of acute moderate- to high-intensity aerobic exercise on markers of immune function and microparticles in renal transplant recipients
| العنوان: | Influence of acute moderate- to high-intensity aerobic exercise on markers of immune function and microparticles in renal transplant recipients |
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| المؤلفون: | Daniel G. D. Nixon, Patrick J. Highton, Alice C. Smith, Naomi Martin, Thomas J. Wilkinson, Nicolette C. Bishop, Jill Neale, Alice E. M. White |
| المصدر: | American Journal of Physiology-Renal Physiology. 318:F76-F85 |
| بيانات النشر: | American Physiological Society, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Physiology, Gastroenterology, Circulating Microparticle, Oxygen Consumption, Immune system, Cell-Derived Microparticles, Internal medicine, medicine, Humans, Aerobic exercise, Postoperative Period, Renal Insufficiency, Renal Insufficiency, Chronic, Exercise, Kidney transplantation, Aged, business.industry, High intensity, Middle Aged, Flow Cytometry, medicine.disease, Kidney Transplantation, Transplant Recipients, Renal transplant, Immune System, Female, business, Biomarkers, Glomerular Filtration Rate, Kidney disease |
| الوصف: | Renal transplant recipients (RTRs) and patients with nondialysis chronic kidney disease display elevated circulating microparticle (MP) counts, while RTRs display immunosuppression-induced infection susceptibility. The impact of aerobic exercise on circulating immune cells and MPs is unknown in RTRs. Fifteen RTRs [age: 52.8 ± 14.5 yr, estimated glomerular filtration rate (eGFR): 51.7 ± 19.8 mL·min−1·1.73 m−2 (mean ± SD)] and 16 patients with nondialysis chronic kidney disease (age: 54.8 ± 16.3 yr, eGFR: 61.9 ± 21.0 mL·min−1·1.73 m−2, acting as a uremic control group), and 16 healthy control participants (age: 52.2 ± 16.2 yr, eGFR: 85.6 ± 6.1 mL·min−1·1.73 m−2) completed 20 min of walking at 60–70% peak O2 consumption. Venous blood samples were taken preexercise, postexercise, and 1 h postexercise. Leukocytes and MPs were assessed using flow cytometry. Exercise increased classical ( P = 0.001) and nonclassical ( P = 0.002) monocyte subset proportions but decreased the intermediate subset ( P < 0.001) in all groups. Exercise also decreased the percentage of platelet-derived MPs that expressed tissue factor in all groups ( P = 0.01), although no other exercise-dependent effects were observed. The exercise-induced reduction in intermediate monocyte percentage suggests an anti-inflammatory effect, although this requires further investigation. The reduction in the percentage of tissue factor-positive platelet-derived MPs suggests reduced prothrombotic potential, although further functional assays are required. Exercise did not cause aberrant immune cell activation, suggesting its safety from an immunological standpoint (ISRCTN38935454). |
| تدمد: | 1522-1466 1931-857X |
| DOI: | 10.1152/ajprenal.00332.2019 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d80b4763dc13477f9d4cf645f8e9ec5 https://doi.org/10.1152/ajprenal.00332.2019 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6d80b4763dc13477f9d4cf645f8e9ec5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221466 1931857X |
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| DOI: | 10.1152/ajprenal.00332.2019 |