Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder
| العنوان: | Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder |
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| المؤلفون: | Gwenaël G.R. Leday, Petra E. Vértes, Sylvia Richardson, Jonathan R. Greene, Tim Regan, Shahid Khan, Robbie Henderson, Tom C. Freeman, Carmine M. Pariante, Neil A. Harrison, V. Hugh Perry, Wayne C. Drevets, Gayle M. Wittenberg, Edward T. Bullmore, Edward Bullmore, Petra Vertes, Rudolf Cardinal, Gwenael Leday, Tom Freeman, David Hume, Zhaozong Wu, Carmine Pariante, Annamaria Cattaneo, Patricia Zunszain, Alessandra Borsini, Robert Stewart, David Chandran, Livia Carvalho, Joshua Bell, Luis Souza-Teodoro, Hugh Perry, Neil Harrison, Wayne Drevets, Gayle Wittenberg, Declan Jones, Annie Stylianou |
| المصدر: | Leday, G G R, Vértes, P E, Richardson, S, Greene, J R, Regan, T, Khan, S, Henderson, R, Freeman, T C, Pariante, C M, Harrison, N A, Perry, V H, Drevets, W C & Wittenberg, G M & Bullmore, E T 2018, ' Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder ', Biological Psychiatry, vol. 83, no. 1, pp. 70-80 . https://doi.org/10.1016/j.biopsych.2017.01.021 Biological Psychiatry Leday, G G R, Vértes, P E, Richardson, S, Greene, J R, Regan, T, Khan, S, Henderson, R, Freeman, T C, Pariante, C M, Harrison, N A, Cardinal, R, Hume, D, Wu, Z, Cattaneo, A, Zunszain, P, Borsini, A, Stewart, R, Chandran, D, Carvalho, L, Bell, J, Souza-Teodoro, L, Perry, H, Harrison, N, Drevets, W, Wittenberg, G, Jones, D, Stylianou, A, Perry, V H, Drevets, W C, Wittenberg, G M & Bullmore, E T 2018, ' Replicable and Coupled Changes in Innate and Adaptive Immune Gene Expression in Two Case-Control Studies of Blood Microarrays in Major Depressive Disorder ', Biological psychiatry, vol. 83, no. 1, pp. 70-80 . https://doi.org/10.1016/j.biopsych.2017.01.021 |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Gene Expression, Biology, Bayesian, Article, Transcriptome, 03 medical and health sciences, 0302 clinical medicine, Immune system, Affymetrix, Gene expression, Humans, Wernicke Encephalopathy, Gene, Biological Psychiatry, Inflammation, Depressive Disorder, Major, Innate immune system, Microarray analysis techniques, Systems, Biomarker, Acquired immune system, Microarray Analysis, Fold change, Immunity, Innate, 030104 developmental biology, Gene Expression Regulation, Case-Control Studies, Immunology, 030217 neurology & neurosurgery, Biomarkers |
| الوصف: | BACKGROUND: Peripheral inflammation is often associated with major depressive disorder (MDD), and immunological biomarkers of depression remain a focus of investigation.METHODS: We used microarray data on whole blood from two independent case-control studies of MDD: the GlaxoSmithKline-High-Throughput Disease-specific target Identification Program [GSK-HiTDiP] study (113 patients and 57 healthy control subjects) and the Janssen-Brain Resource Company study (94 patients and 100 control subjects). Genome-wide differential gene expression analysis (18,863 probes) resulted in a p value for each gene in each study. A Bayesian method identified the largest p-value threshold (q = .025) associated with twice the number of genes differentially expressed in both studies compared with the number of coincidental case-control differences expected by chance.RESULTS: A total of 165 genes were differentially expressed in both studies with concordant direction of fold change. The 90 genes overexpressed (or UP genes) in MDD were significantly enriched for immune response to infection, were concentrated in a module of the gene coexpression network associated with innate immunity, and included clusters of genes with correlated expression in monocytes, monocyte-derived dendritic cells, and neutrophils. In contrast, the 75 genes underexpressed (or DOWN genes) in MDD were associated with the adaptive immune response and included clusters of genes with correlated expression in T cells, natural killer cells, and erythroblasts. Consistently, the MDD patients with overexpression of UP genes also had underexpression of DOWN genes (correlation > .70 in both studies).CONCLUSIONS: MDD was replicably associated with proinflammatory activation of the peripheral innate immune system, coupled with relative inactivation of the adaptive immune system, indicating the potential of transcriptional biomarkers for immunological stratification of patients with depression. |
| وصف الملف: | application/pdf; text |
| اللغة: | English |
| تدمد: | 0006-3223 |
| DOI: | 10.1016/j.biopsych.2017.01.021 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d739fa0a97d4204f3af4ba11dfb37f5 https://www.pure.ed.ac.uk/ws/files/40281562/1_s2.0_S0006322317316177_main.pdf |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6d739fa0a97d4204f3af4ba11dfb37f5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00063223 |
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| DOI: | 10.1016/j.biopsych.2017.01.021 |