Health monitoring in birds using bio-loggers and whole blood transcriptomics
| العنوان: | Health monitoring in birds using bio-loggers and whole blood transcriptomics |
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| المؤلفون: | Gustaw Eriksson, Karsten Klein, Elinor Jax, Robert H. S. Kraus, Hanna Borlinghaus, Helene Pendl, Wolfgang Fiedler, Bernd Timmermann, Stefan T. Börno, Inge Müller, Martin Wikelski, Falk Schreiber, Evi Fricke, Katharine E. Magor |
| المصدر: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
| بيانات النشر: | Nature Publishing Group UK, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0106 biological sciences, 0301 basic medicine, Science, Immunology, Gene regulatory network, Disease, Biology, 010603 evolutionary biology, 01 natural sciences, Article, Gene regulatory networks, Body Temperature, Transcriptome, Avian Proteins, 03 medical and health sciences, Immune system, Heart Rate, ddc:570, Anseriformes, Exome Sequencing, Animals, Computer Simulation, Gene expression, Gene ontology, Gene regulatory networks, High-throughput screening, Immunology, Infectious diseases, Innate immune cell, Non-model organisms, RNA sequencing, Whole blood, Multidisciplinary, Sequence Analysis, RNA, Gene Expression Profiling, High-throughput screening, Outbreak, High-Throughput Nucleotide Sequencing, RNA sequencing, Non-model organisms, Gene expression profiling, Innate immune cells, 030104 developmental biology, Gene Expression Regulation, Influenza A virus, Vector (epidemiology), Influenza in Birds, Population Surveillance, Medicine, Infectious diseases, Gene ontology, Gene expression, Blood Chemical Analysis |
| الوصف: | Monitoring and early detection of emerging infectious diseases in wild animals is of crucial global importance, yet reliable ways to measure immune status and responses are lacking for animals in the wild. Here we assess the usefulness of bio-loggers for detecting disease outbreaks in free-living birds and confirm detailed responses using leukocyte composition and large-scale transcriptomics. We simulated natural infections by viral and bacterial pathogens in captive mallards (Anas platyrhynchos), an important natural vector for avian influenza virus. We show that body temperature, heart rate and leukocyte composition change reliably during an acute phase immune response. Using genome-wide gene expression profiling of whole blood across time points we confirm that immunostimulants activate pathogen-specific gene regulatory networks. By reporting immune response related changes in physiological and behavioural traits that can be studied in free-ranging populations, we provide baseline information with importance to the global monitoring of zoonotic diseases. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4dcbf7d52cd57ac72cb61df8721969 http://europepmc.org/articles/PMC8144624 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6d4dcbf7d52cd57ac72cb61df8721969 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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