Efficacy of intra-arterial nimodipine in the treatment of cerebral vasospasm complicating subarachnoid haemorrhage

التفاصيل البيبلوغرافية
العنوان: Efficacy of intra-arterial nimodipine in the treatment of cerebral vasospasm complicating subarachnoid haemorrhage
المؤلفون: K. P. Lau, Cathryn Hui
المصدر: Clinical radiology. 60(9)
سنة النشر: 2005
مصطلحات موضوعية: Adult, Male, Subarachnoid hemorrhage, Vasodilator Agents, Blood Pressure, Cerebral vasospasm, Heart Rate, Papaverine, medicine, Humans, Infusions, Intra-Arterial, Vasospasm, Intracranial, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, Nimodipine, Aged, medicine.diagnostic_test, business.industry, Vasospasm, General Medicine, Middle Aged, Subarachnoid Hemorrhage, medicine.disease, Cerebral Angiography, Blood pressure, medicine.anatomical_structure, Treatment Outcome, Anesthesia, Female, business, Tomography, X-Ray Computed, medicine.drug, Artery, Cerebral angiography
الوصف: AIM To examine the efficacy and safety of nimodipine as an alternative to papaverine for the treatment of cerebral vasospasm following subarachnoid haemorrhage. METHODS We retrospectively reviewed the procedure reports, anaesthetic records, clinical charts and CT and angiographic images of 9 patients who had received intra-arterial nimodipine; 1 of these patients received both nimodipine and papaverine. The difference in arterial luminal diameter before and after treatment was calculated as a percentage change. RESULTS The average dose of nimodipine administered per vessel was 3.3 mg. The mean increase in arterial diameter was 66.6% in the vasospastic segment. There was no significant change in blood pressure of any of the subjects during endovascular treatment of vasospasm. CONCLUSION Intra-arterial nimodipine is effective in improving angiographic vasospasm complicating subarachnoid haemorrhage. Further studies aimed at examining the clinical benefits of nimodipine are warranted, particularly in view of the low risk of adverse side effects of nimopidine when compared with papaverine.
تدمد: 0009-9260
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d39b15c21e227d0bf262fb45d2f8026
https://pubmed.ncbi.nlm.nih.gov/16124986
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....6d39b15c21e227d0bf262fb45d2f8026
قاعدة البيانات: OpenAIRE