التفاصيل البيبلوغرافية
| العنوان: |
Immune Recovery in Adult Patients after Myeloablative Dual Umbilical Cord Blood, Matched Sibling, and Matched Unrelated Donor Hematopoietic Cell Transplantation |
| المؤلفون: |
John P. Chute, Ashley Morris, Paul Szabolcs, Nelson J. Chao, Gregory D. Sempowski, Lun Wei Chiou, John Andrew Livingston, Donna Niedzwiecki, Keith M. Sullivan, Mitchell E. Horwitz, Cristina Gasparetto, Gwynn D. Long, Jacalyn McPherson, David A. Rizzieri, Junya Kanda, Gloria Broadwater, Jeffrey Hale |
| المصدر: |
Biology of Blood and Marrow Transplantation. 18(11):1664-1676.e1 |
| بيانات النشر: |
Elsevier BV, 2012. |
| سنة النشر: |
2012 |
| مصطلحات موضوعية: |
Adult, Male, Transplantation Conditioning, medicine.medical_treatment, T-Lymphocytes, Matched sibling transplantation, Myeloablative Agonist, Graft vs Host Disease, Histocompatibility Testing, Cord Blood Stem Cell Transplantation, Hematopoietic stem cell transplantation, Post-thymic T cell reconstitution, Umbilical cord, Article, 03 medical and health sciences, 0302 clinical medicine, Antigens, CD, Medicine, Humans, Transplantation, Homologous, Lymphocyte Count, Prospective Studies, Immune recovery, Matched unrelated donor transplantation, Transplantation, business.industry, Dual umbilical cord blood transplantation, Siblings, Graft Survival, Hematopoietic Stem Cell Transplantation, Recovery of Function, Hematology, Middle Aged, Myeloablative Agonists, 3. Good health, medicine.anatomical_structure, surgical procedures, operative, 030220 oncology & carcinogenesis, Immunology, Female, TCR excision DNA circles (TRECs), business, Unrelated Donors, CD8, 030215 immunology |
| الوصف: |
Immunologic reconstitution after allogeneic hematopoietic cell transplantation is a critical component of successful outcome. Umbilical cord blood (UCB) transplantation in adult recipients is associated with slow and often inadequate immune recovery. We characterized the kinetics and extent of immune recovery in 95 adult recipients after a dual UCB (n = 29) and matched sibling donor (n = 33) or matched unrelated donor (n = 33) transplantation. All patients were treated with myeloablative conditioning. There were no differences in the immune recovery profile of matched sibling donor and matched unrelated donor recipients. Significantly lower levels of CD3+, CD4+, and CD8+ T cells were observed in UCB recipients until 6 months after transplantation. Lower levels of regulatory T cells persisted until 1 year after transplantation. Thymopoiesis as measured by TCR rearrangement excision circle was comparable among all recipients by 6 months after transplantation. In a subset of patients 1 year after transplantation with similar levels of circulating T cells and TCR rearrangement excision circle, there was no difference in TCR diversity. Compared to HLA-identical matched sibling donor and matched unrelated donor adult hematopoietic cell transplantation recipients, quantitative lymphoid recovery in UCB transplantation recipients is slower in the first 3 months, but these differences disappeared by 6 to 12 months after transplantation. |
| تدمد: |
1083-8791 |
| DOI: |
10.1016/j.bbmt.2012.06.005 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1f84e3dfdb918640ae36e120ba2ac3 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....6d1f84e3dfdb918640ae36e120ba2ac3 |
| قاعدة البيانات: |
OpenAIRE |