Assaying the Effect of Levodopa on the Evaluation of Risk in Healthy Humans
| العنوان: | Assaying the Effect of Levodopa on the Evaluation of Risk in Healthy Humans |
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| المؤلفون: | Elizabeth Fagan, Nicholas D. Wright, Mkael Symmonds, Raymond J. Dolan |
| المصدر: | PLoS ONE PLoS ONE, Vol 8, Iss 7, p e68177 (2013) |
| بيانات النشر: | Public Library of Science, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Psychopharmacology, Dopamine, Social and Behavioral Sciences, Biochemistry, Antiparkinson Agents, Levodopa, Behavioral Neuroscience, 0302 clinical medicine, Medicine, Psychology, Young adult, Multidisciplinary, 05 social sciences, Dopaminergic, Neurochemistry, Variance (accounting), Preference, Mental Health, Behavioral Pharmacology, Female, Neurochemicals, Algorithms, medicine.drug, Research Article, Adult, medicine.medical_specialty, Drugs and Devices, Adolescent, Science, Cognitive Neuroscience, Decision Making, Models, Psychological, 050105 experimental psychology, 03 medical and health sciences, Young Adult, Physical medicine and rehabilitation, Risk-Taking, Reward, Humans, 0501 psychology and cognitive sciences, Biology, Behavior, business.industry, Risk evaluation, Gambling, business, Risk taking, 030217 neurology & neurosurgery, Neuroscience |
| الوصف: | In humans, dopamine is implicated in reward and risk-based decision-making. However, the specific effects of dopamine augmentation on risk evaluation are unclear. Here we sought to measure the effect of 100 mg oral levodopa, which enhances synaptic release of dopamine, on choice behaviour in healthy humans. We use a paradigm without feedback or learning, which solely isolates effects on risk evaluation. We present two studies (n = 20; n = 20) employing a randomised, placebo-controlled, within-subjects design. We manipulated different dimensions of risk in a controlled economic paradigm. We test effects on risk-reward tradeoffs, assaying both aversion to variance (the spread of possible outcomes) and preference for relative losses and gains (asymmetry of outcomes - skewness), dissociating this from potential non-specific effects on choice randomness using behavioural modelling. There were no systematic effects of levodopa on risk attitudes, either for variance or skewness. However, there was a drift towards more risk-averse behaviour over time, indicating that this paradigm was sensitive to detect changes in risk-preferences. These findings suggest that levodopa administration does not change the evaluation of risk. One possible reason is that dopaminergic influences on decision making may be due to changing the response to reward feedback. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf263fbd1138b1c0e2bacf7e932c0a2 http://europepmc.org/articles/PMC3700857 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6cf263fbd1138b1c0e2bacf7e932c0a2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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