Contribution of Murine Double Minute 2 Genotypes to Colorectal Cancer Risk in Taiwan
| العنوان: | Contribution of Murine Double Minute 2 Genotypes to Colorectal Cancer Risk in Taiwan |
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| المؤلفون: | Wen Shin Chang, Chia-Wen Tsai, Da Tian Bau, Chun Kai Fu, Cheng Nan Wu, Te Cheng Yueh, Tzu Ching Shih, Yi Wen Hung, Tao-Wei Ke, Yi Liang Lai, Shou Cheng Wang, Yun Chi Wang, Ming Hsien Wu, Shih Wei Hsu |
| المصدر: | Cancer Genomics - Proteomics. 15:405-411 |
| بيانات النشر: | Anticancer Research USA Inc., 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Alcohol Drinking, Genotype, Colorectal cancer, Taiwan, Polymorphism, Single Nucleotide, Biochemistry, Mice, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, Risk Factors, Polymorphism (computer science), Internal medicine, Genetics, medicine, Animals, Humans, Genetic Predisposition to Disease, Precision Medicine, Allele, neoplasms, Molecular Biology, Allele frequency, Early Detection of Cancer, Genetic Association Studies, business.industry, Case-control study, Proto-Oncogene Proteins c-mdm2, Odds ratio, Prognosis, medicine.disease, Matrix Metalloproteinases, Confidence interval, 030104 developmental biology, 030220 oncology & carcinogenesis, Female, Colorectal Neoplasms, business, Research Article |
| الوصف: | Background/Aim: The genomic role of human mouse double minute 2 (MDM2) in colorectal cancer (CRC) is unclear, therefore, our study aimed to evaluate the contribution of MDM2 genotype to the risk of CRC in Taiwan. Materials and Methods: In this case–control study, MDM2 SNP309 T to G (rs2279744) genotypes were determined and their association with CRC risk were investigated among 362 patients with CRC and 362 age- and gender-matched healthy controls in central Taiwan. In addition, the interaction of MDM2 SNP309 genotypes with personal behaviors and clinicopathological features were also examined. Results: The percentage of variant GG for the MDM2 SNP309 genotype was 30.9% in the CRC group and 24.0% in the control group, respectively (odds ratio (OR)=1.78, 95% confidence interval (CI)=1.25-2.86, p=0.0057). The allelic frequency distribution analysis showed that the variant G allele of MDM2 SNP309 conferred a significantly increased susceptibility to CRC compared with the wild-type T allele (OR=1.32, 95% CI=1.14-1.69, p=0.0062). As for the gene-lifestyle interaction, there was an obvious joint effect of MDM2 SNP309 GG genotype on the risk of CRC among ever-smokers and non-alcohol drinkers, but not non-smoker or alcohol drinker subgroups. No statistically significant correlation was observed between MDM2 SNP309 genotypic distributions and age, gender, tumor size, location or metastasis status. Conclusion: The genotypes of MDM2 SNP309 may allow forr early detection of and predictor for CRC risk, especially among smokers and non-alcohol drinkers, but not for prognosis. The combined effects of MDM2 SNP309 and other genes (such as matrix metalloproteinases) on CRC susceptibility and prognosis, should also be taken into consideration in the era of precision medicine. |
| تدمد: | 1790-6245 1109-6535 |
| DOI: | 10.21873/cgp.20099 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cd32f228e49b3552572a6dc970031ee https://doi.org/10.21873/cgp.20099 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6cd32f228e49b3552572a6dc970031ee |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17906245 11096535 |
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| DOI: | 10.21873/cgp.20099 |