Connection between Parameters of Erythron System and Myelofibrosis during Chronic Myeloleukemia, Multiply Mieloma, and Chronic Lymphatic Leukemia
| العنوان: | Connection between Parameters of Erythron System and Myelofibrosis during Chronic Myeloleukemia, Multiply Mieloma, and Chronic Lymphatic Leukemia |
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| المؤلفون: | S R Senchukova, E. V. Sholenberg, I. V. Kachesov, T. Yu. Dolgikh |
| المصدر: | Bulletin of Experimental Biology and Medicine. 164:382-385 |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Chronic lymphocytic leukemia, Bone Marrow Cells, Chronic lymphatic leukemia, General Biochemistry, Genetics and Molecular Biology, Hemoglobins, 03 medical and health sciences, 0302 clinical medicine, Erythroid Cells, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Erythropoiesis, Myelofibrosis, Multiple myeloma, business.industry, Case-control study, Myeloid leukemia, General Medicine, Fibroblasts, Middle Aged, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, 030104 developmental biology, medicine.anatomical_structure, Primary Myelofibrosis, Case-Control Studies, 030220 oncology & carcinogenesis, Erythrocyte Count, Female, Bone marrow, Multiple Myeloma, business |
| الوصف: | Clinical and morphological investigation of myelofibrosis was performed in patients with chronic myeloid leukemia, multiple myeloma, and chronic lymphocytic leukemia by analyzing the morphometric parameters of trepan-biopsy material. The correlation between changes in the parameters of erythron system and distribution of myelofibrosis were analyzed. In patients with chronic myeloid leukemia, multiple myeloma, and chronic lymphocytic leukemia, the maximum suppression of the erythron was observed against the background of severe myelofibrosis. The degree of erythron inhibition correlated with distribution of the fibrous tissue in the bone marrow. In patients with onset of chronic phase of chronic myeloid leukemia and active phase of multiple myeloma, the total number of erythroid cells was lower than in active phase of chronic lymphocytic leukemia irrespective of the degree of myelofibrosis. Erythrocyte count and hemoglobin content in the peripheral blood were lower in patients with multiple myeloma and chronic lymphocytic leukemia in comparison with the corresponding parameters in patients with chronic myeloid leukemia irrespective of the severity of myelofibrosis. |
| تدمد: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-018-3994-0 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c87de8ea13863727b1a378c8204cccb https://doi.org/10.1007/s10517-018-3994-0 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....6c87de8ea13863727b1a378c8204cccb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15738221 00074888 |
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| DOI: | 10.1007/s10517-018-3994-0 |