Predictive factors for pharyngocutaneous fistulization after total laryngectomy: a Dutch Head and Neck Society audit
| العنوان: | Predictive factors for pharyngocutaneous fistulization after total laryngectomy: a Dutch Head and Neck Society audit |
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| المؤلفون: | Frans J. M. Hilgers, Vincent van der Noort, Remco de Bree, Simone E. J. Eerenstein, Michiel W. M. van den Brekel, Boudewijn E. C. Plaat, Robert P. Takes, Ton P. M. Langeveld, Simone E. Bernard, Liset Lansaat, Martin Lacko |
| المساهمون: | ACLC (FGw), MKA AMC (OII, ACTA), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Maxillofacial Surgery (AMC), Graduate School, CCA - Cancer Treatment and Quality of Life, Other departments, Oral and Maxillofacial Surgery, Otorhinolaryngology and Head and Neck Surgery, Otolaryngology / Head & Neck Surgery, CCA - Cancer Treatment and quality of life, RS: GROW - R2 - Basic and Translational Cancer Biology, MUMC+: MA Keel Neus Oorheelkunde (9) |
| المصدر: | European Archives of Oto-Rhino-Laryngology, 275(3), 783-794. Springer Verlag On behalf of the Dutch Head and Neck Society 2018, ' Predictive factors for pharyngocutaneous fistulization after total laryngectomy: a Dutch Head and Neck Society audit ', European Archives of Oto-Rhino-Laryngology, vol. 275, no. 3, pp. 783-794 . https://doi.org/10.1007/s00405-017-4861-8 European Archives of Oto-Rhino-Laryngology, 275(3), 783-794. SPRINGER European Archives of Oto-Rhino-Laryngology, 275, 783-794 European Archives of Oto-Rhino-Laryngology, 275, 3, pp. 783-794 European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS), 275(3), 783-794. Springer Verlag European Archives of Oto-Rhino-Laryngology, 275(3), 783-794. Springer-Verlag Dutch Head and Neck Society 2018, ' Predictive factors for pharyngocutaneous fistulization after total laryngectomy : a Dutch Head and Neck Society audit ', European Archives of Oto-Rhino-Laryngology, vol. 275, no. 3, pp. 783-794 . https://doi.org/10.1007/s00405-017-4861-8 European Archives of Oto-Rhino-Laryngology, 275(3), 783-794. Springer |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Pediatrics, SURGERY, medicine.medical_treatment, Total laryngectomy, Cutaneous Fistula, 0302 clinical medicine, Tracheotomy, Postoperative Complications, Pharyngectomy, Risk Factors, Outcome Assessment, Health Care, 030223 otorhinolaryngology, COMPLICATIONS, Medical Audit, Incidence (epidemiology), Incidence, General Medicine, Middle Aged, FISTULA, CANCER, Laryngectomy, 030220 oncology & carcinogenesis, Neck Dissection, Female, Predictive factors, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], RADIOTHERAPY, Adult, medicine.medical_specialty, CARCINOMA, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, SDG 3 - Good Health and Well-being, medicine, MANAGEMENT, Humans, Risk factor, Predicted pharyngocutaneous fistulization percentages, METAANALYSIS, Aged, Retrospective Studies, Pharyngocutaneous fistulization, business.industry, National audit, Retrospective cohort study, Neck dissection, Pharyngeal Diseases, medicine.disease, Comorbidity, Otorhinolaryngology, RISK-FACTORS, Respiratory Tract Fistula, business, COMORBIDITY |
| الوصف: | Background: Incidences of pharyngocutaneous fistulization (PCF) after total laryngectomy (TL) reported in the literature vary widely, ranging from 2.6 to 65.5%. Comparison between different centers might identify risk factors, but also might enable improvements in quality of care. To enable this on a national level, an audit in the 8 principle Dutch Head and Neck Centers (DHNC) was initiated. Methods: A retrospective chart review of all 324 patients undergoing laryngectomy in a 2-year (2012 and 2013) period was performed. Overall PCF%, PCF% per center and factors predictive for PCF were identified. Furthermore, a prognostic model predicting the PCF% per center was developed. To provide additional data, a survey among the head and neck surgeons of the participating centers was carried out. Results: Overall PCF% was 25.9. The multivariable prediction model revealed that previous treatment with (chemo)radiotherapy in combination with a long interval between primary treatment and TL, previous tracheotomy, near total pharyngectomy, neck dissection, and BMI < 18 were the best predictors for PCF. Early oral intake did not influence PCF rate. PCF% varied quite widely between centers, but for a large extend this could be explained with the prediction model. PCF performance rate (difference between the PCF% and the predicted PCF%) per DHNC, though, shows that not all differences are explained by factors established in the prediction model. However, these factors explain enough of the differences that, compensating for these factors, hospital is no longer independently predictive for PCF. Conclusions: This nationwide audit has provided valid comparative PCF data confirming the known risk factors from the literature which are important for counseling on PCF risks. Data show that variations in PCF% in the DHNCs (in part) are explainable by the variations in these predictive factors. Since elective neck dissection is a major risk factor for PCF, it only should be performed on well funded indication. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0937-4477 |
| DOI: | 10.1007/s00405-017-4861-8 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4b4e557bc1d616cfcb4ebaf466db30 https://dare.uva.nl/personal/pure/en/publications/predictive-factors-for-pharyngocutaneous-fistulization-after-total-laryngectomy(70bb22ba-f99b-4b15-a037-5c35c79a0448).html |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6c4b4e557bc1d616cfcb4ebaf466db30 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09374477 |
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| DOI: | 10.1007/s00405-017-4861-8 |