Exploring the epigenetic drug discovery landscape
| العنوان: | Exploring the epigenetic drug discovery landscape |
|---|---|
| المؤلفون: | Veda Prachayasittikul, Philip Prathipati, Chanin Nantasenamat, Jarl E. S. Wikberg, Prapimpun Wongchitrat, Kanokwan Seenprachawong, Chuleeporn Phanus-umporn, Aijaz Ahmad Malik, Aungkura Supokawej, Nalini Schaduangrat, Virapong Prachayasittikul, Reny Pratiwi |
| المصدر: | Expert Opinion on Drug Discovery. 12:345-362 |
| بيانات النشر: | Informa UK Limited, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Epigenomics, 0301 basic medicine, Drug, media_common.quotation_subject, Druggability, Computational biology, Biology, Bioinformatics, Epigenesis, Genetic, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Chemogenomics, Animals, Humans, Molecular Targeted Therapy, Epigenetics, media_common, Drug discovery, Drug Repositioning, Drug repositioning, 030104 developmental biology, chemistry, Cheminformatics, Drug Design, 030220 oncology & carcinogenesis |
| الوصف: | Epigenetic modification has been implicated in a wide range of diseases and the ability to modulate such systems is a lucrative therapeutic strategy in drug discovery. Areas covered: This article focuses on the concepts and drug discovery aspects of epigenomics. This is achieved by providing a survey of the following concepts: (i) factors influencing epigenetics, (ii) diseases arising from epigenetics, (iii) epigenetic enzymes as druggable targets along with coverage of existing FDA-approved drugs and pharmacological agents, and (iv) drug repurposing/repositioning as a means for rapid discovery of pharmacological agents targeting epigenetics. Expert opinion: Despite significant interests in targeting epigenetic modifiers as a therapeutic route, certain classes of target proteins are heavily studied while some are less characterized. Thus, such orphan target proteins are not yet druggable with limited report of active modulators. Current research points towards a great future with novel drugs directed to the many complex multifactorial diseases of humans, which are still often poorly understood and difficult to treat. |
| تدمد: | 1746-045X 1746-0441 |
| DOI: | 10.1080/17460441.2017.1295954 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bfaa83895f70d4581461d96449320ad https://doi.org/10.1080/17460441.2017.1295954 |
| رقم الانضمام: | edsair.doi.dedup.....6bfaa83895f70d4581461d96449320ad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1746045X 17460441 |
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| DOI: | 10.1080/17460441.2017.1295954 |