Anthranoyl-substituted Norditerpene Alkaloids from Aconitum vulparia Rchb. and Their Cytotoxic Activities
| العنوان: | Anthranoyl-substituted Norditerpene Alkaloids from Aconitum vulparia Rchb. and Their Cytotoxic Activities |
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| المؤلفون: | D Csupor, István Zupkó, Pál Szabó, Judit Hohmann, Peter Forgo |
| المصدر: | Zeitschrift für Naturforschung B. 62:135-141 |
| بيانات النشر: | Walter de Gruyter GmbH, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | biology, Chemistry, Stereochemistry, Alkaloid, Aconitum vulparia, General Medicine, General Chemistry, biology.organism_classification, Nmr data, HeLa, Cytotoxic T cell, Cytotoxicity, Two-dimensional nuclear magnetic resonance spectroscopy, Heteronuclear single quantum coherence spectroscopy |
| الوصف: | Extensive chromatographic purification of the alkaloid fraction of Aconitum vulparia Rchb. led to the isolation of a new norditerpene alkaloid, vulparine (1), besides the known compounds septentriodine (2), finetiadine (3), anthranoyllycoctonine (4), N-methyl-N-deethyllycoctonine (5) and delectinine (6). The structure of the new compound was determined by means of HRMS, 1D and 2D NMR spectroscopy. Detailed NMR studies, including 1H-1H COSY, NOESY, HSQC and HMBC experiments, resulted in complete and unambiguous 1H chemical shift assignments for 2 and 6, and revision of some 13C NMR data. Compounds 1 - 4 were evaluated for their cytotoxic activities, and 1, 3 and 4 were found to exhibit marginal cell growth inhibitory activity against breast adenocarcinoma (MCF-7) and cervix adenocarcinoma (HeLa) cells. |
| تدمد: | 1865-7117 0932-0776 |
| DOI: | 10.1515/znb-2007-0122 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7f4283ce74df1754e1aba98fc8e20d https://doi.org/10.1515/znb-2007-0122 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6b7f4283ce74df1754e1aba98fc8e20d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18657117 09320776 |
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| DOI: | 10.1515/znb-2007-0122 |