Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function
| العنوان: | Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function |
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| المؤلفون: | Jacinta Jacob, Kulachelvy Ratnasothy, Dominic A. Boardman, Robert I. Lechler, Qi Peng, Anthony Dorling, Sim L. Tung, Giovanna Lombardi, Daniel McCluskey, Lesley A. Smyth |
| المصدر: | Frontiers in Immunology, Vol 10 (2019) Peng, Q, Ratnasothy, K, Boardman, D A, Jacob, J, Tung, S L, Mccluskey, D, Smyth, L A, Lechler, R I, Dorling, A & Lombardi, G 2019, ' Protease Activated Receptor 4 as a Novel Modulator of Regulatory T Cell Function ', Frontiers in Immunology, vol. 10, no. JUN, 1311, pp. 1-14 . https://doi.org/10.3389/fimmu.2019.01311 Frontiers in Immunology |
| بيانات النشر: | Frontiers Media SA, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, lcsh:Immunologic diseases. Allergy, Proteases, Cell type, Phosphatase and tensin homolog on chromosome 10 (PTEN), protease activated receptor 4 (PAR4), Regulatory T cell, immunoregulation, forkhead box protein O1 (FoxO1), Immunology, chemical and pharmacologic phenomena, Protease activated receptor 4 (PAR4), Biology, T-Lymphocytes, Regulatory, Autoimmune Diseases, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, phosphatase and tensin homolog on chromosome 10 (PTEN), PI3K/Akt signaling pathway, Immune Tolerance, medicine, Animals, Immunology and Allergy, Forkhead box protein O1 (FoxO1), IL-2 receptor, Receptor, Cells, Cultured, Original Research, Mice, Inbred BALB C, Regulatory T cells (Tregs), Anaphylatoxin receptors, PTEN Phosphohydrolase, Immunoregulation, FOXP3, Forkhead Transcription Factors, hemic and immune systems, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, regulatory T cells (Tregs), Receptors, Thrombin, lcsh:RC581-607, Signal Transduction, 030215 immunology |
| الوصف: | Regulatory T cells (Tregs) are a subpopulation of T cells that maintain immunological tolerance. In inflammatory responses the function of Tregs is tightly controlled by several factors including signaling through innate receptors such as Toll like receptors and anaphylatoxin receptors allowing an effective immune response to be generated. Protease-activated receptors (PARs) are another family of innate receptors expressed on multiple cell types and involved in the pathogenesis of autoimmune disorders. Whether proteases are able to directly modulate Treg function is unknown. Here, we show using two complimentary approaches that signaling through PAR-4 influences the expression of CD25, CD62L, and CD73, the suppressive capacity, and the stability of Tregs, via phosphorylation of FoxO1 and negative regulation of PTEN and FoxP3. Taken together, our results demonstrate an important role of PAR4 in tuning the function of Tregs and open the possibility of targeting PAR4 to modulate immune responses. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1664-3224 |
| DOI: | 10.3389/fimmu.2019.01311 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0c93e777fb3c90accd7841d9a3cc3b |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6b0c93e777fb3c90accd7841d9a3cc3b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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| DOI: | 10.3389/fimmu.2019.01311 |