Analysis of Complete Genome Sequence of Acinetobacter baumannii Strain ATCC 19606 Reveals Novel Mobile Genetic Elements and Novel Prophage
| العنوان: | Analysis of Complete Genome Sequence of Acinetobacter baumannii Strain ATCC 19606 Reveals Novel Mobile Genetic Elements and Novel Prophage |
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| المؤلفون: | Lucia Blasco, Lauren N Tillman, Mohammad Hamidian, María Tomás, Joyce To, Garry S. A. Myers |
| المصدر: | Microorganisms, Vol 8, Iss 1851, p 1851 (2020) Microorganisms Volume 8 Issue 12 |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Microbiology (medical), Transposable element, antibiotic resistance, complete genome, Acinetobacter baumannii ATCC 19606, Microbiology, Genome, Article, 03 medical and health sciences, Plasmid, Virology, plasmid, Gene, lcsh:QH301-705.5, Prophage, 030304 developmental biology, Whole genome sequencing, Genetics, 0303 health sciences, biology, 030306 microbiology, ST52 and Multi-Locus Sequence Typing (MLST), biology.organism_classification, Acinetobacter baumannii, lcsh:Biology (General), Mobile genetic elements |
| الوصف: | Acinetobacter baumannii isolate ATCC 19606 was recovered in the US prior to 1948. It has been used as a reference and model organism in many studies involving antibiotic resistance and pathogenesis of A. baumannii, while, until recently, a complete genome of this strain was not available. Here, we present an analysis of the complete 3.91-Mbp genome sequence, generated via a combination of short-read sequencing (Illumina) and long-read sequencing (MinION), and show it contains two small cryptic plasmids and a novel complete prophage of size 41.2 kb. We also characterised several regions of the ATCC 19606 genome, leading to the identification of a novel cadmium/mercury transposon, which was named Tn6551. ATCC 19606 is an antibiotic-sensitive strain, but a comparative analysis of all publicly available ST52 strains predicts a resistance to modern antibiotics by the accumulation of antibiotic-resistance genes via plasmids in recent isolates that belong to this sequence type. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-2607 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ac1b369fa2658485a1ef12772fe2a3f https://www.mdpi.com/2076-2607/8/12/1851 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6ac1b369fa2658485a1ef12772fe2a3f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20762607 |
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