Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry
| العنوان: | Estimation of Admission D-dimer Cut-off Value to Predict Venous Thrombotic Events in Hospitalized COVID-19 Patients: Analysis of the SEMI-COVID-19 Registry |
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| المؤلفون: | Vicente Giner-Galvañ, Jesús Javier González Igual, Luis Manzano, Anthony Gurjian Arena, Philip Erick Wikman-Jorgensen, Juan Santos, Santiago Jesús Freire Castro, Jeffrey Oskar Magallanes Gamboa, Manuel Méndez Bailón, Javier García Alegría, Ruth Calderón Hernaiz, Julio González Moraleja, Jaime Laureiro, Manuel Rubio-Rivas, Judit Aranda Lobo, María José García Blanco, Amara González Noya, Francisco Arnalich-Fernández, Ricardo Gómez Huelgas, José Luis Beato Pérez, Juan Antonio Vargas Núñez, Luis Arribas Pérez, Carlos Lumbreras Bermejo, Carles García-Cervera, Jesús Díez-Manglano |
| المصدر: | Zaguán. Repositorio Digital de la Universidad de Zaragoza instname JOURNAL OF GENERAL INTERNAL MEDICINE r-FISABIO. Repositorio Institucional de Producción Científica |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, pulmonary embolism, Coronavirus disease 2019 (COVID-19), venous thrombotic event, Deep vein, Gastroenterology, Tachypnea, deep vein thrombosis, Fibrin Fibrinogen Degradation Products, Basal (phylogenetics), Internal medicine, D-dimer, mental disorders, Internal Medicine, medicine, Humans, cardiovascular diseases, Registries, Retrospective Studies, Venous Thrombosis, business.industry, SARS-CoV-2, COVID-19, Retrospective cohort study, Venous Thromboembolism, medicine.disease, Thrombosis, Pulmonary embolism, Hospitalization, medicine.anatomical_structure, medicine.symptom, business |
| الوصف: | Background: Venous thrombotic events (VTE) are frequent in COVID-19, and elevated plasma D-dimer (pDd) and dyspnea are common in both entities. Objective: To determine the admission pDd cut-off value associated with in-hospital VTE in patients with COVID-19. Methods: Multicenter, retrospective study analyzing the at-admission pDd cut-off value to predict VTE and anticoagulation intensity along hospitalization due to COVID-19. Results: Among 9386 patients, 2.2% had VTE: 1.6% pulmonary embolism (PE), 0.4% deep vein thrombosis (DVT), and 0.2% both. Those with VTE had a higher prevalence of tachypnea (42.9% vs. 31.1%; p = 0.0005), basal O2 saturation 1.0 µg/ml treated with prophylactic dose (p < 0.0001), 28.8% for pDd for patients with pDd >2.0 µg/ml treated with intermediate dose (p = 0.0001), and 31.3% for those with pDd >3.0 µg/ml and full anticoagulation (p = 0.0183). Conclusions: In hospitalized patients with COVID-19, a pDd value greater than 3.0 µg/ml can be considered to screen VTE and to consider full-dose anticoagulation. © 2021, Society of General Internal Medicine. |
| وصف الملف: | application/pdf |
| تدمد: | 1525-1497 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a77e04125513b170f363f5c30b8889f http://zaguan.unizar.es/record/110609 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6a77e04125513b170f363f5c30b8889f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15251497 |
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