Power-Doppler perfusion phenotype in RA patients is dependent on anti-citrullinated peptide antibody status, not on rheumatoid factor
| العنوان: | Power-Doppler perfusion phenotype in RA patients is dependent on anti-citrullinated peptide antibody status, not on rheumatoid factor |
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| المؤلفون: | M Feuchtenberger, E C Schwaneck, T Wech, Ottar Gadeholt |
| المصدر: | Rheumatology International. 39:1019-1025 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, Wrist Joint, musculoskeletal diseases, medicine.medical_specialty, Multivariate analysis, Immunology, Peptide, Gastroenterology, Anti-Citrullinated Protein Antibodies, Arthritis, Rheumatoid, Rheumatology, Rheumatoid Factor, immune system diseases, Internal medicine, medicine, Humans, Immunology and Allergy, Rheumatoid factor, skin and connective tissue diseases, Aged, chemistry.chemical_classification, biology, business.industry, Ultrasonography, Doppler, Middle Aged, Phenotype, Pathophysiology, chemistry, biology.protein, Female, Antibody, business, Perfusion |
| الوصف: | It is not known whether there are any consistent non-serological differences between seropositive and seronegative rheumatoid arthritis, and if any, whether they depend upon rheumatoid factor (RF), anti-citrullinated peptide antibodies (ACPA), or both. In a pilot study, we showed that the two forms could be differentiated using power-Doppler sonography (PDS), and that the difference is ACPA dependent. This extended study explored whether the previous findings could be confirmed. 103 patients 51 ACPA positive (ACPA +), 52 ACPA negative (ACPA −) with active wrist arthritis were examined using PDS. By means of a temporal image series, pulsatility was evaluated over a 3–5-s period, maximum and minimum perfusion signal were determined using a computer program counting the number of coloured pixels for each frame. Maxima (Pmax) and minima (Pmin) were determined, and the standardized peak-to-peak amplitude sA was calculated (sA = (Pmax − Pmin)/Pmax). This parameter was then compared for ACPA + and ACPA- patients. In addition, a multivariate regression was performed, to determine which factors influence sA. sA differed significantly between ACPA + and ACPA- patients [20% (13–26) vs. 41% (32–57), p |
| تدمد: | 1437-160X 0172-8172 |
| DOI: | 10.1007/s00296-019-04256-1 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4b17b2413cfd3252e3f97714d97c71 https://doi.org/10.1007/s00296-019-04256-1 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....6a4b17b2413cfd3252e3f97714d97c71 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1437160X 01728172 |
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| DOI: | 10.1007/s00296-019-04256-1 |