Iodine Intake Increases IP-10 Expression in the Serum and Thyroids of Rats with Experimental Autoimmune Thyroiditis
| العنوان: | Iodine Intake Increases IP-10 Expression in the Serum and Thyroids of Rats with Experimental Autoimmune Thyroiditis |
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| المؤلفون: | Liu Shou-jun, Jun Yu, Si-lu Cui |
| المصدر: | International Journal of Endocrinology International Journal of Endocrinology, Vol 2014 (2014) |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | medicine.medical_specialty, Article Subject, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Rat model, chemistry.chemical_element, Iodine, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Autoimmune thyroiditis, Endocrinology, Interferon, Internal medicine, Medicine, Iodine intake, lcsh:RC648-665, Endocrine and Autonomic Systems, business.industry, Thyroid, medicine.disease, medicine.anatomical_structure, Distilled water, chemistry, Thyroglobulin, business, medicine.drug, Research Article |
| الوصف: | Here, we sought to establish an experimental autoimmune thyroiditis rat model induced by bovine thyroglobulin (bTg) injection and to investigate pathological changes and variations in serum interferon-γ-inducible protein of 10 kDa (IP-10) in thyroid tissue following iodine treatment. Four-week-old female Lewis rats(n=135)were randomly divided into normal (NC), thyroglobulin (TG), HI, HI+TG, HII, and HII+TG groups; rats in the NC and TG groups drank only distilled water (iodine concentration: 10 μg/L), rats in the HI and HI+TG groups were given water containing 25.7 mg/L iodine, and rats in the HII and HII+TG groups were given water containing 423.3 mg/L iodine. Rats in the TG, HI+TG, and HII+TG groups were immunized with 0.1 mL bTg (8 mg/mL) in incomplete Freund’s adjuvant once every 2 weeks for 6 weeks. Compared with the NC group, the TG, HI+TG, and HII+TG groups exhibited higher iodine intake and increased thyroid weights with increasing iodine doses(P<0.05). The high iodine intake in the TG group was associated with increased CD4+T cells and serum IP-10. Thus, high iodine consumption aggravated the inflammatory reaction in the thyroid and mild high iodine consumption increased serum IP-10 levels after induction with bTg. |
| وصف الملف: | text/xhtml |
| تدمد: | 1687-8337 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a0e77d04edd03b993b7a71a9d688348 https://pubmed.ncbi.nlm.nih.gov/24707288 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6a0e77d04edd03b993b7a71a9d688348 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16878337 |
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