Intravenous Bone Marrow Mononuclear Cells Transplantation Improves the Effect of Training in Chronic Stroke Mice
| العنوان: | Intravenous Bone Marrow Mononuclear Cells Transplantation Improves the Effect of Training in Chronic Stroke Mice |
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| المؤلفون: | Yuka Okinaka, Yukiko Takeuchi, Akihiko Taguchi, Akie Kikuchi-Taura, Yuko Ogawa, Orie Saino |
| المصدر: | Frontiers in Medicine, Vol 7 (2020) Frontiers in Medicine |
| بيانات النشر: | Frontiers Media S.A., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | lcsh:R5-920, business.industry, Cerebral infarction, Therapeutic effect, General Medicine, Brief Research Report, medicine.disease, cerebral infarction, Peripheral blood mononuclear cell, stroke, Cell therapy, Transplantation, chronic, medicine.anatomical_structure, Anesthesia, medicine, Medicine, bone marrow mononuclear cell, Bone marrow, cardiovascular diseases, cell therapy, Vein, business, lcsh:Medicine (General), Stroke |
| الوصف: | There is no effective treatment for chronic stroke if the acute or subacute phase is missed. Rehabilitation alone cannot easily achieve a dramatic recovery in function. In contrast to significant therapeutic effects of bone marrow mononuclear cells (BM-MNC) transplantation for acute stroke, mild and non-significant effects have been shown for chronic stroke. In this study, we have evaluated the effect of a combination of BM-MNC transplantation and neurological function training in chronic stroke. The effect of BM-MNC on neurological functional was tested four weeks after permanent middle cerebral artery occlusion (MCAO) insult in mice. BM-MNC (1 × 105cells in 100 μl PBS) were injected into the vein of MCAO model mice, followed by behavioral tests as functional evaluations. Interestingly, there was a significant therapeutic effect of BM-MNC only when repeated training was performed. This suggested that cell therapy alone was not sufficient for chronic stroke treatment; however, training with cell therapy was effective. The combination of these differently targeted therapies provided a significant benefit in the chronic stroke mouse model. Therefore, targeted cell therapy via BM-MNC transplantation with appropriate training presents a promising novel therapeutic option for patients in the chronic stroke period. |
| اللغة: | English |
| DOI: | 10.3389/fmed.2020.535902/full |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a09aed05a0988f3fc0470997c70a27c https://www.frontiersin.org/articles/10.3389/fmed.2020.535902/full |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6a09aed05a0988f3fc0470997c70a27c |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.3389/fmed.2020.535902/full |
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