Association between Chromosome 4 and mercury accumulation in muscle of the three-spined stickleback (Gasterosteus aculeatus)
| العنوان: | Association between Chromosome 4 and mercury accumulation in muscle of the three-spined stickleback (Gasterosteus aculeatus) |
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| المؤلفون: | Anna Kordas, Federico C. F. Calboli, Gudrun De Boeck, Filip Volckaert, Vyshal Delahaut, Lieven Bervoets, Io S. Deflem, Joost A. M. Raeymaekers, Pascal I. Hablützel, Bart Hellemans |
| المصدر: | Evolutionary Applications Evolutionary applications Evolutionary Applications, Vol 14, Iss 10, Pp 2553-2567 (2021) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Special Issue Articles, Three-spined stickleback, BIOAVAILABILITY, Genome-wide association study, adaptation, 010501 environmental sciences, 01 natural sciences, pollution, 2. Zero hunger, Genetics, next generation sequencing, 0303 health sciences, biology, SUB-ARCTIC LAKE, Stickleback, BIOACCUMULATION, Matematikk og Naturvitenskap: 400::Zoologiske og botaniske fag: 480::Økotoksikologi: 489 [VDP], three‐spined stickleback, L, ADAPTIVE EVOLUTION, General Agricultural and Biological Sciences, Life Sciences & Biomedicine, environment, mercury, Evolution, selection, Single-nucleotide polymorphism, Locus (genetics), Special Issue Original Article, Gasterosteus, 03 medical and health sciences, POLLUTION, FISH, QH359-425, POPULATION-STRUCTURE, EXPOSURE, Biology, Allele frequency, Ecology, Evolution, Behavior and Systematics, three-spined stickleback, 030304 developmental biology, 0105 earth and related environmental sciences, Matematikk og Naturvitenskap: 400::Kjemi: 440::Miljøkjemi, naturmiljøkjemi: 446 [VDP], Evolutionary Biology, Science & Technology, biology.organism_classification, Chromosome 4, 13. Climate action, Matematikk og Naturvitenskap: 400::Basale biofag: 470::Genetikk og genomikk: 474 [VDP], RESPONSES |
| الوصف: | Anthropogenic stressors, such as pollutants, act as selective factors that can leave measurable changes in allele frequencies in the genome. Metals are of particular concern among pollutants, because of interference with vital biological pathways. We use the three-spined stickleback as a model for adaptation to mercury pollution in natural populations. We collected sticklebacks from 21 locations in Flanders (Belgium), measured the accumulated levels of mercury in the skeletal muscle tissue, and genotyped the fish by sequencing (GBS). The spread of muscle mercury content across locations was considerable, ranging from 21.5 to 327 ng/g dry weight (DW). We then conducted a genome-wide association study (GWAS) between 28,450 single nucleotide polymorphisms (SNPs) and the accumulated levels of mercury, using different approaches. Based on a linear mixed model analysis, the GWAS yielded multiple hits with a single top hit on Chromosome 4, with eight more SNPs suggestive of association. A second approach, a latent factor mixed model analysis, highlighted one single SNP on Chromosome 11. Finally, an outlier test identified one additional SNP on Chromosome 4 that appeared under selection. Out of all ten SNPs we identified as associated with mercury in muscle, three SNPs all located on Chromosome 4 and positioned within a 2.5 kb distance of an annotated gene. Based on these results and the genome coverage of our SNPs, we conclude that the selective effect of mercury pollution in Flanders causes a significant association with at least one locus on Chromosome 4 in three-spined stickleback. ispartof: EVOLUTIONARY APPLICATIONS vol:14 issue:10 pages:2553-2567 ispartof: location:England status: published |
| وصف الملف: | application/pdf; Electronic-eCollection |
| اللغة: | English |
| تدمد: | 1752-4571 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6944d974fe9f385b6f56a2a4dde333dd https://hdl.handle.net/11250/2978546 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6944d974fe9f385b6f56a2a4dde333dd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17524571 |
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