Evaluation of the interaction between anti-apoptotic Bcl-2 protein family mRNA expression and autophagy gene Bcl-1 expression in Egyptian SLE patients
| العنوان: | Evaluation of the interaction between anti-apoptotic Bcl-2 protein family mRNA expression and autophagy gene Bcl-1 expression in Egyptian SLE patients |
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| المؤلفون: | Noha M Khalil, Rasha N. Yousef, Hecham Gamal AlDeen, Mervat Essam Behiry, Ingy Ashmawy, Abeer Ramadan, Eman Awadallah, Asmaa Ali, Alshaimaa R. Alnaggar |
| المصدر: | Lupus. 31:1186-1190 |
| بيانات النشر: | SAGE Publications, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Rheumatology, Autophagy, Humans, Lupus Erythematosus, Systemic, Beclin-1, Egypt, RNA, Messenger, Apoptosis Regulatory Proteins |
| الوصف: | Objectives Autophagy is a complex cellular process that maintains homeostasis in systemic lupus erythematosus. Abnormally high expression of Bcl-2 was observed in B and T lymphocytes in the peripheral blood in SLE patients. These may be responsible for the survival of self-reactive lymphocytes and the development of lupus, and the study aims at evaluating interaction between apoptosis and autophagy in Egyptian lupus patients. Methods Sixty patients with SLE were diagnosed by fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria for SLE and sixty healthy age and sex matched control. All patients were subjected to full medical history and clinical examination. Activity was assessed using SLEDAI-2K score. Gene expression of Beclin-1, Bcl-2-L2, and Bcl-2 was measured. Results The study revealed that the expression of anti-apoptotic Bcl-2 and Bcl-2-L2 was significantly higher in SLE patients than control subjects, as well as the major apoptotic agent (Beclin-1) mRNA, p = 0.03, < 0.001 and 0.02, respectively. The apoptotic Beclin-1 mRNA was positively correlated with SLE disease severity index, r = 0.25; p = 0.0.4; therefore, our results showed that expression of the Beclin-1 was significantly higher in SLE patients than control ( p < 0.02). Conclusion Our results showed that expression of the Beclin 1 were significantly higher in SLE patients than control ( p < 0.02). |
| تدمد: | 1477-0962 0961-2033 |
| DOI: | 10.1177/09612033221106302 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68da6aae28081fd071a8657f9c65c289 https://doi.org/10.1177/09612033221106302 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....68da6aae28081fd071a8657f9c65c289 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14770962 09612033 |
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| DOI: | 10.1177/09612033221106302 |