Recent Advances in the Use of Exosomes in Sjögren's Syndrome
| العنوان: | Recent Advances in the Use of Exosomes in Sjögren's Syndrome |
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| المؤلفون: | Sang Lin, Yupeng Huang, Geng Yin, Qi-Bing Xie, Sheng Ye, Ruicen Li |
| المصدر: | Frontiers in Immunology Frontiers in Immunology, Vol 11 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | lcsh:Immunologic diseases. Allergy, 0301 basic medicine, Mini Review, Immunology, Inflammation, exosomes, Biology, immune response, Immunomodulation, 03 medical and health sciences, 0302 clinical medicine, Immune system, Drug Delivery Systems, Circular RNA, Sicca syndrome, microRNA, medicine, Immunology and Allergy, Animals, Humans, treatment, Immunogenicity, RNA, biomarkers, Microvesicles, Biological Therapy, 030104 developmental biology, Sjogren's Syndrome, Sjögren’s syndrome, Cancer research, medicine.symptom, lcsh:RC581-607, 030215 immunology |
| الوصف: | Sjögren’s syndrome (SS) is a chronic autoimmune disorder of the exocrine glands mediated by lymphocytic infiltrates damaging the body tissues and affecting the life quality of patients. Although traditional methods of diagnosis and treatment for SS are effective, in the time of personalized medicine, new biomarkers, and novel approaches are required for the detection and treatment of SS. Exosomes represent an emerging field in the discovery of biomarkers and the management of SS. Exosomes, a subtype of extracellular vesicles, are secreted by various cell types and can be found in most bodily fluids. Exosomes are packed with cytokines and other proteins, bioactive lipids, and nucleic acids (mRNA, circular RNA, non-coding RNA, tRNA, microRNA, genomic DNA, and ssDNA), and transport such cargo between cells. Evidence has indicated that exosomes may play roles in processes such as the modulation of the immune response and activation of inflammation. Moreover, due to features such as stability, low immunogenicity and toxicity, long half-life, and the capacity to penetrate the blood-brain barrier, exosomes have also emerged as therapeutic tools for SS. In this review, we summarize existing literature regarding the biogenesis, isolation, and function of exosomes, specifically focusing on exosomes as novel biomarkers and their potential therapeutic uses in SS. |
| تدمد: | 1664-3224 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d25aee101d6dedd3867fa79f9ef963 https://pubmed.ncbi.nlm.nih.gov/32903777 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....68d25aee101d6dedd3867fa79f9ef963 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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