Serotyping and Antibiotic Susceptibility of Invasive Streptococcus agalactiae in Egyptian Patients with or without Diabetes Mellitus
| العنوان: | Serotyping and Antibiotic Susceptibility of Invasive Streptococcus agalactiae in Egyptian Patients with or without Diabetes Mellitus |
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| المؤلفون: | Mohamed A Sakr, Bob Gertz, Sawsan H M El Tayeb Hassan, Abdelnaser Abdelaty Gadallah, Aya M Mahros, Beal Bernard, Marwa Tahoon, Mohamed Fathey Elgazzar, Abd-ElAleem A El-Gendy, Fatma Eldesoky Ahmed, Mohamed Meligy Ahmed, Ghada Abd El Tawab, Hassan Ahmed Elzohry, Mohamed El-Tonsy El-Sayed, Mohammed Hussien Ahmed, Shimaa Y Kamel, Hazem M Zakaria |
| المصدر: | Am J Trop Med Hyg |
| بيانات النشر: | American Society of Tropical Medicine and Hygiene, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Antibiotic sensitivity, Erythromycin, Microbial Sensitivity Tests, Serogroup, medicine.disease_cause, Reproductive Tract Infections, Meningitis, Bacterial, Streptococcus agalactiae, Microbiology, Neonatal meningitis, Young Adult, chemistry.chemical_compound, Streptococcal Infections, Virology, Drug Resistance, Bacterial, Diabetes Mellitus, Pneumonia, Bacterial, Humans, Medicine, Molecular Epidemiology, Synovitis, business.industry, Clindamycin, Articles, Middle Aged, medicine.disease, Diabetic Foot, Anti-Bacterial Agents, Lincomycin, Otitis Media, Infectious Diseases, chemistry, Urinary Tract Infections, Linezolid, Vancomycin, Egypt, Female, Parasitology, business, medicine.drug |
| الوصف: | Streptococcus agalactiae serotype distribution and its antibiotic susceptibility affect disease prevention strategies, but the serotype distribution varies among patient groups. The objectives of this study were to establish the group B Streptococcus (GBS) serotype distribution in patients from Egypt and to assess antibiotic sensitivity of invasive GBS isolates. A total of 490 patients participated in this multicenter study; 160 had urinary tract infection, 115 complained of diabetic foot ulcers, 125 men had genital tract infections, and 30 women females had genital tract infections. Others had bronchopneumonia, otitis media, synovitis, or meningitis. Serotyping of the isolated GBS was performed at the CDC in the United States. Antibiotic sensitivity patterns were determined using the disk diffusion method. In men, the most common serotypes were II, III, and V, whereas types Ia, II, III, and V were isolated from women. Macrolides (erythromycin) resistance occurred in 4.1% of the isolates; 10.2% were resistant to both clindamycin and inducible resistance of macrolides, lincomycin, and streptogramin; 17.3% were resistant to quinolones; and 95.9% were resistant to tetracyclines. GBS primarily infected the urinary tract, skin, soft tissue, and genital tract in both genders. Isolates were sensitive to beta-lactam drugs, vancomycin, and linezolid; 14.0% were resistant to macrolides with or without clindamycin. Only 6.0% of the strains were sensitive to tetracyclines. Although GBS causes invasive infections in Egyptian adults, it rarely causes neonatal meningitis or sepsis. Future studies should determine whether GBS isolates are transmitted sexually, by performing a follow-up study of the partner of the infected patient. |
| تدمد: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.21-0300 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68a3b73701ef07e503d88029a58815e7 https://doi.org/10.4269/ajtmh.21-0300 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....68a3b73701ef07e503d88029a58815e7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14761645 00029637 |
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| DOI: | 10.4269/ajtmh.21-0300 |