Therapeutic effects on intestinal Behcet's disease of an intravenous drug delivery system using dexamethasone incorporated in lipid emulsion
| العنوان: | Therapeutic effects on intestinal Behcet's disease of an intravenous drug delivery system using dexamethasone incorporated in lipid emulsion |
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| المؤلفون: | Masaya Ohana, Kazuichi Okazaki, Toshiki Nishi, Hiroshi Takakuwa, Kazushige Uchida, Akiyoshi Nishio, Akihiro Okano, Suguru Uose, Tsutomu Chiba, Toshiyuki Itoh, Chiharu Kawanami, Hiroshi Nakase |
| المصدر: | Journal of Gastroenterology and Hepatology. 16:1306-1308 |
| بيانات النشر: | Wiley, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Male, Fat Emulsions, Intravenous, medicine.medical_specialty, medicine.drug_class, medicine.medical_treatment, Anti-Inflammatory Agents, Behcet's disease, Gastroenterology, Dexamethasone, Drug Delivery Systems, Ileal Ulcer, Oral administration, Internal medicine, medicine, Humans, Chemotherapy, Hepatology, business.industry, Behcet Syndrome, Therapeutic effect, Middle Aged, medicine.disease, Surgery, Prednisolone, Corticosteroid, Female, business, medicine.drug |
| الوصف: | Recurrent intestinal ulcer is a frequent problem in the management of Behçet's disease. However, no standard therapy for intestinal Beheçt's disease has been established. We report two patients with intestinal Behçet disease and recurrent ileal ulcers who were treated successfuly with a lipid emulsion of dexamethasone. In one patient, the cecal ulcer did not relapse after the intravenous administration initiation of a lipid emulsion of dexamethasone once a week, despite the discontinuation of prednisolone. In the other patient, the cecal ulcer showed a healing tendency, and oral administration of prednisolone was reduced from 40 to 15 mg/day after intravenous administration of a lipid emulsion of dexamethasone. Both patients experienced no complications associated with the administration of the emulsion. These results suggest that an intravenous drug delivery system using a lipid emulsion of dexamethasone is useful for treatment of intestinal Behçet's disease. |
| تدمد: | 1440-1746 0815-9319 |
| DOI: | 10.1046/j.1440-1746.2001.02510.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689e76ea1de5e1624a99e0c0594ac1ed https://doi.org/10.1046/j.1440-1746.2001.02510.x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....689e76ea1de5e1624a99e0c0594ac1ed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14401746 08159319 |
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| DOI: | 10.1046/j.1440-1746.2001.02510.x |