A nematode-derived, mitochondrial stress signaling-regulated peptide exhibits broad antibacterial activity
| العنوان: | A nematode-derived, mitochondrial stress signaling-regulated peptide exhibits broad antibacterial activity |
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| المؤلفون: | Mark W. Pellegrino, Yves Balikosa, Joseph M. Boll, Siraje Arif Mahmud, Mohammed Adnan Qureshi, Charlton Nguyen, Madhab Sapkota |
| المصدر: | Biology Open article-version (VoR) Version of Record Biology Open, Vol 10, Iss 5 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cell Membrane Permeability, QH301-705.5, Cell Survival, Science, ved/biology.organism_classification_rank.species, Antimicrobial peptides, Mitochondrion, Mitochondrial UPR, General Biochemistry, Genetics and Molecular Biology, Cell Line, 03 medical and health sciences, Stress, Physiological, Mitochondrial unfolded protein response, Animals, Amino Acid Sequence, Biology (General), Model organism, Caenorhabditis elegans, Caenorhabditis elegans Proteins, 030304 developmental biology, Innate immunity, 0303 health sciences, Caenacins, Innate immune system, biology, Bacteria, 030306 microbiology, ved/biology, Effector, Stress response, Antimicrobial, biology.organism_classification, Immunity, Innate, Cell biology, Mitochondria, CNC-4, Unfolded Protein Response, Antimicrobial peptide, General Agricultural and Biological Sciences, Antimicrobial Peptides, Research Article, Signal Transduction |
| الوصف: | A dramatic rise of infections with antibiotic-resistant bacterial pathogens continues to challenge the healthcare field due to the lack of effective treatment regimes. As such, there is an urgent need to develop new antimicrobial agents that can combat these multidrug-resistant superbugs. Mitochondria are central regulators of metabolism and other cellular functions, including the regulation of innate immunity pathways involved in the defense against infection. The mitochondrial unfolded protein response (UPRmt) is a stress-activated pathway that mitigates mitochondrial dysfunction through the regulation of genes that promote recovery of the organelle. In the model organism Caenorhabditis elegans, the UPRmt also mediates an antibacterial defense program that combats pathogen infection, which promotes host survival. We sought to identify and characterize antimicrobial effectors that are regulated during the UPRmt. From our search, we discovered that the antimicrobial peptide CNC-4 is upregulated during this stress response. CNC-4 belongs to the caenacin family of antimicrobial peptides, which are predominantly found in nematodes and are known to have anti-fungal properties. Here, we find that CNC-4 also possesses potent antimicrobial activity against a spectrum of bacterial species and report on its characterization. Summary: The caenacin antimicrobial peptide CNC-4 is regulated by a mitochondrial recovery pathway and exhibits broad antibacterial activity. |
| تدمد: | 2046-6390 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67febdfded40ee722e1785484cf6b0c9 https://pubmed.ncbi.nlm.nih.gov/34184732 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....67febdfded40ee722e1785484cf6b0c9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20466390 |
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