MATE-1 modulation by kinin B1 receptor enhances cisplatinefflux from renal cells
| العنوان: | MATE-1 modulation by kinin B1 receptor enhances cisplatinefflux from renal cells |
|---|---|
| المؤلفون: | Frederick Wasinski, Michael Bader, Gabriel Rufino Estrela, Niels Olsen Saraiva Câmara, Raphael José Ferreira Felizardo, Laura L. Souza, Ronaldo C. Araujo |
| المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Organic Cation Transport Proteins, medicine.drug_class, Clinical Biochemistry, Pharmacology, Biology, Kidney, Receptor, Bradykinin B1, Gene Knockout Techniques, Mice, 03 medical and health sciences, 0302 clinical medicine, Downregulation and upregulation, medicine, Animals, Receptor, Molecular Biology, IMUNOLOGIA, Cisplatin, Acute kidney injury, Cell Biology, General Medicine, Acute Kidney Injury, Kinin, medicine.disease, Receptor antagonist, Bradykinin B1 Receptor Antagonists, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Gene Expression Regulation, 030220 oncology & carcinogenesis, Efflux, medicine.drug |
| الوصف: | Cisplatin is a drug widely used in chemotherapy that frequently causes severe renal dysfunction. Organic transporters have an important role to control the absorption and excretion of cisplatin in renal cells. Deletion and blockage of kinin B1 receptor has already been show to protect against cisplatin-induced acute kidney injury. To test whether it exerts its protective function by modulating the organic transporters in kidney, we studied kinin B1 receptor knockout mice and treatment with a receptor antagonist at basal state and in presence of cisplatin. Cisplatin administration caused downregulation of renal organic transporters; in B1 receptor knockout mice, this downregulation of organic transporters in kidney was absent; and treatment by a B1 receptor antagonist attenuated the downregulation of the transporter MATE-1. Moreover, kinin B1 receptor deletion and blockage at basal state resulted in higher renal expression of MATE-1. Moreover we observed that kinin B1 receptor deletion and blockage result in less accumulation of platinum in renal tissue. Thus, we propose that B1 receptor deletion and blockage protect the kidney from cisplatin-induced acute kidney injury by upregulating the expression of MATE-1, thereby increasing the efflux of cisplatin from renal cells. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d7503435a36a81a4d2790f28a8acd8 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....67d7503435a36a81a4d2790f28a8acd8 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |