التفاصيل البيبلوغرافية
العنوان:
Combinatorial synthesis of CCR5 antagonists
المؤلفون:
Anthony Carella , Kevin T. Chapman , Christopher A. Willoughby , Martin S. Springer , Lorraine Malkowitz , Janet Lineberger , Emilio A. Emini , Karen Holmes , Keith G. Rosauer , Scott C. Berk , Gwen Carver , Michael W. Miller , Silvia Degrado , Sandra L. Gould , Daria J. Hazuda , Renee Danzeisen , Joseph Kessler , William A. Schleif
المصدر:
Bioorganic & Medicinal Chemistry Letters . 11:3137-3141
بيانات النشر:
Elsevier BV, 2001.
سنة النشر:
2001
مصطلحات موضوعية:
Library design , Combinatorial Chemistry Techniques , biology , Chemistry , Chemokine receptor CCR5 , Stereochemistry , Organic Chemistry , Clinical Biochemistry , Antagonist , virus diseases , Pharmaceutical Science , CCR5 receptor antagonist , Combinatorial synthesis , Biochemistry , Chemical synthesis , Structure-Activity Relationship , CCR5 Receptor Antagonists , Drug Discovery , HIV-1 , biology.protein , Molecular Medicine , Structure–activity relationship , Molecular Biology
الوصف:
Herein we report the preparation of a combinatorial library of compounds with potent CCR5 binding affinity. The library design was aided by SAR generated in a traditional medicinal chemistry effort. Compounds with novel combinations of subunits were discovered that have high binding affinity for the CCR5 receptor. A potent CCR5 antagonist from the library, compound 11 was found to have moderate anti-HIV-1 activity.
تدمد:
0960-894X
DOI:
10.1016/s0960-894x(01)00652-7
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67a680536f6412241be19b4fc45d177e https://doi.org/10.1016/s0960-894x (01)00652-7
Rights:
CLOSED
رقم الانضمام:
edsair.doi.dedup.....67a680536f6412241be19b4fc45d177e
قاعدة البيانات:
OpenAIRE