التفاصيل البيبلوغرافية
| العنوان: |
A critical Assessment of the Genotoxicity Profile of the Fungicide Tricyclazole |
| المؤلفون: |
Jyotigna Mehta, B. Bhaskar Gollapudi, Marco Corvaro |
| المصدر: |
Environmental and molecular mutagenesisREFERENCES. 61(3) |
| سنة النشر: |
2019 |
| مصطلحات موضوعية: |
Epidemiology, Health, Toxicology and Mutagenesis, Mutagen, 010501 environmental sciences, Gene mutation, Biology, medicine.disease_cause, 01 natural sciences, Ames test, 03 medical and health sciences, In vivo, medicine, Animals, Humans, Genetics (clinical), 030304 developmental biology, 0105 earth and related environmental sciences, 0303 health sciences, Mutagenicity Tests, In vitro toxicology, DNA, Molecular biology, Fungicides, Industrial, Thiazoles, Mutagenesis, Micronucleus test, Reproductive toxicity, Genotoxicity, DNA Damage, Mutagens |
| الوصف: |
Tricyclazole (8-methyl-[1,2,4]triazolo[3,4-b][1,3]benzothiazole) is a fungicide used globally on rice for treatment of the seasonal rice blast disease. Human exposure to this fungicide can occur via dietary and nondietary routes. In a battery of in vitro assays, tricyclazole did not induce gene mutations in bacteria (Ames test) or at the Hprt locus of CHO cells. It was also negative for the induction of micronuclei in human lymphocyte cultures and unscheduled DNA synthesis (UDS) in primary rat hepatocyte. Paradoxically, tricyclazole induced a mutagenic response at the Tk locus of the mouse lymphoma L5178Ycells (MLA), which occurred equally among small/large colony phenotypes. Selection of preexisting mutants leading to a false-positive response in the MLA was ruled out in follow-up experiments. In vivo, tricyclazole was negative in the rat liver UDS assay, mouse bone micronucleus test and a transgenic (MutaMouse) gene mutation assay in glandular stomach, liver, and kidney. Other supporting evidence for the lack of genotoxicity for tricyclazole comes from an in vivo study for sister chromatid exchanges in Chinese hamsters, and a dominant lethal test in the male germ cells of mice. The combined evidence from the genotoxicity studies together with the evidence from toxicokinetic, carcinogenicity, developmental, and reproductive toxicity studies confirm that mutagenicity does not occur in relevant in vivo systems. Data were also compared to potential animal and human exposure, mechanistic data on biological targets and data on analogues, confirming adequacy of the available data for hazard identification and risk assessment. Environ. Mol. Mutagen. 61:300-315, 2020. © 2019 Wiley Periodicals, Inc. |
| تدمد: |
1098-2280 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67939b09ca2a7a917f165d44591c88ae
https://pubmed.ncbi.nlm.nih.gov/31633836 |
| Rights: |
CLOSED |
| رقم الانضمام: |
edsair.doi.dedup.....67939b09ca2a7a917f165d44591c88ae |
| قاعدة البيانات: |
OpenAIRE |