التفاصيل البيبلوغرافية
العنوان:
Diaryl piperidines as CB1 receptor antagonists
المؤلفون:
Samuel Chackalamannil , Yan Xia , Hongwu Wang , Michael W. Miller , Charles Lee Jayne , Sarah W. Li , Jean E. Lachowicz , Andrew Stamford , William J. Greenlee , Jack D. Scott , Timothy J. Kowalski , George Boykow , Ruth A. Duffy , Brian D. Spar
المصدر:
Bioorganic & Medicinal Chemistry Letters . 20:1278-1283
بيانات النشر:
Elsevier BV, 2010.
سنة النشر:
2010
مصطلحات موضوعية:
Cannabinoid receptor , Stereochemistry , medicine.medical_treatment , Clinical Biochemistry , Mice, Obese , Pharmaceutical Science , Biochemistry , Chemical synthesis , Eating , Mice , Structure-Activity Relationship , chemistry.chemical_compound , Piperidines , Receptor, Cannabinoid, CB1 , In vivo , Drug Discovery , medicine , Animals , Potency , Obesity , Receptor , Molecular Biology , Chemistry , Organic Chemistry , Antagonist , Diet , Molecular Medicine , Cannabinoid , Piperidine , Protein Binding
الوصف:
The syntheses and SAR investigations of novel CB(1) receptor antagonists based on a 1,2-diaryl piperidine core have been described. Optimization of this core afforded a compound with robust in vivo potency by reducing food intake in a mouse DIO model.
تدمد:
0960-894X
DOI:
10.1016/j.bmcl.2009.11.075
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67935b84a0ae84dd7db77bb2a7c97ceb https://doi.org/10.1016/j.bmcl.2009.11.075
Rights:
CLOSED
رقم الانضمام:
edsair.doi.dedup.....67935b84a0ae84dd7db77bb2a7c97ceb
قاعدة البيانات:
OpenAIRE