Vaccines for the Paramyxoviruses and Pneumoviruses: Successes, Candidates, and Hurdles
| العنوان: | Vaccines for the Paramyxoviruses and Pneumoviruses: Successes, Candidates, and Hurdles |
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| المؤلفون: | Charles J. Russell, Julia L. Hurwitz, Eric A. F. Simões |
| المصدر: | Viral Immunology. 31:133-141 |
| بيانات النشر: | Mary Ann Liebert Inc, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, viruses, Immunology, Drug Evaluation, Preclinical, Respiratory Syncytial Virus Infections, Virus, Measles virus, 03 medical and health sciences, Human metapneumovirus, Pneumovirinae, Virology, Drug Discovery, Animals, Humans, Medicine, Clinical Trials as Topic, Paramyxoviridae Infections, biology, business.industry, Viral Vaccines, biology.organism_classification, Sendai virus, Which Vaccines Are Missing?, Pneumoviridae, Clinical trial, Human Parainfluenza Virus, 030104 developmental biology, Paramyxovirinae, Molecular Medicine, Respiratory virus, business |
| الوصف: | Human parainfluenza viruses (family Paramyxoviridae), human metapneumovirus, and respiratory syncytial virus (family Pneumoviridae) infect most infants and children within the first few years of life and are the etiologic agents for many serious acute respiratory illnesses. These virus infections are also associated with long-term diseases that impact quality of life, including asthma. Despite over a half-century of vaccine research, development, and clinical trials, no vaccine has been licensed to date for the paramyxoviruses or pneumoviruses for the youngest infants. In this study, we describe the recent reclassification of paramyxoviruses and pneumoviruses into distinct families by the International Committee on the Taxonomy of Viruses. We also discuss some past unsuccessful vaccine trials and some currently preferred vaccine strategies. Finally, we discuss hurdles that must be overcome to support successful respiratory virus vaccine development for the youngest children. |
| تدمد: | 1557-8976 0882-8245 |
| DOI: | 10.1089/vim.2017.0137 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672e3ebec0a719e03d3444b9c5f1716a https://doi.org/10.1089/vim.2017.0137 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....672e3ebec0a719e03d3444b9c5f1716a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15578976 08828245 |
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| DOI: | 10.1089/vim.2017.0137 |