Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway
| العنوان: | Anti-neuroinflammatory Effects of 12-Dehydrogingerdione in LPS-Activated Microglia through Inhibiting Akt/IKK/NF-κB Pathway and Activating Nrf-2/HO-1 Pathway |
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| المؤلفون: | Ming-Yao Gu, Jiu Liang Xu, Hyun Ok Yang, Dong Zhao, Li Jun Zhang, Shi Yong Ryu |
| المصدر: | Biomolecules & Therapeutics |
| بيانات النشر: | The Korean Society of Applied Pharmacology, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, 12-Dehydrogingerdione, Prostaglandin, IκB kinase, Pharmacology, Ginger, Biochemistry, Nitric oxide, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Protein kinase B, Signaling pathway, Interleukin, NF-κB, Heme oxygenase, 030104 developmental biology, chemistry, Neuro-inflammation, 030220 oncology & carcinogenesis, Molecular Medicine, Tumor necrosis factor alpha, Original Article, Microglial cells |
| الوصف: | Ginger, one of worldwide consumed dietary spice, is not only famous as food supplements, but also believed to exert a variety of remarkable pharmacological activity as herbal remedies. In this study, a ginger constituent, 12-dehydrogingerdione (DHGD) was proven that has comparable anti-inflammatory activity with positive control 6-shogaol in inhibiting LPS-induced interleukin (IL)-6, tumor necrosis factor (TNF)-α, prostaglandin (PG) E₂, nitric oxide (NO), inducible NO synthase (iNOS) and cyclooxygenase (COX)-2, without interfering with COX-1 in cultured microglial cells. Subsequent mechanistic studies indicate that 12-DHGD may inhibit neuro-inflammation through suppressing the LPS-activated Akt/IKK/NF-κB pathway. Furthermore, 12-DHGD markedly promoted the activation of NF-E2-related factor (Nrf)-2 and heme oxygenase (HO)-1, and we demonstrated that the involvement of HO-1 on the production of pro-inflammatory mediators such as NO and TNF-α by using a HO-1 inhibitor, Zinc protoporphyrin (Znpp). These results indicate that 12-DHGD may protect against neuro-inflammation by inhibiting Akt/IKK/IκB/NF-κB pathway and promoting Nrf-2/HO-1 pathway. |
| اللغة: | English |
| تدمد: | 2005-4483 1976-9148 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6709e20c9aacfe0f4ad4f17576575a75 http://europepmc.org/articles/PMC6319549 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6709e20c9aacfe0f4ad4f17576575a75 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20054483 19769148 |
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