Purpose: To evaluate the change in the severity of hypoxic-ischemic encephalopathy (HIE) and associated morbidities between pre-and during COVID-19 pandemic periods in Canada. Methods: We conducted a retrospective cohort study extracting the data from level-3 NICUs participating in Canadian Neonatal Network (CNN). The primary outcome was a composite of death in the first week after birth and/or stage 3 HIE (Sarnat and Sarnat). Secondary outcomes included rate and severity of HIE among admitted neonates, overall mortality, brain injury on magnetic resonance imaging (MRI), neonates requiring resuscitation, organ dysfunction, and rates of therapeutic hypothermia (TH) usage. We included 1591 neonates with gestational age ≥36 weeks with HIE during the specified periods: pandemic cohort April 1st to December 31st of 2020; pre-pandemic cohort between April 1st to December 31st of 2017, 2018, and 2019. We calculated the odds ratio (OR) and confidence intervals (CI).Results: We observed no difference in the primary outcome (15% vs. 16%; OR 1.08; 95%CI 0.78-1.48), mortality in the first week of life (6% vs. 6%; OR 1.10, 95%CI 0.69-1.75), overall mortality, neonates requiring resuscitation, organ dysfunction, TH usage, and rate of brain injury. In the ad-hoc analysis, per 1000 live births, there was an increase in the rate of infants with HIE and TH use. Conclusions: Severity of HIE, associated morbidities and mortality were not significantly different during the pandemic compared to a pre-pandemic period in Canada. Anticipated risks and difficulties in accessing healthcare have not increased the mortality and morbidities in neonates with HIE in Canada.