Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000–2015
| العنوان: | Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000–2015 |
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| المؤلفون: | Perez-Nadales E, Alastruey-Izquierdo A, Linares-Sicilia M, Soto-Debran J, Abdala E, Garcia-Rodriguez J, Montejo M, Munoz P, Lleti M, Rezusta A, de Pipaon M, Yanez L, Merino E, Campos-Herrero M, Costa-Mateo J, Fortun J, Garcia-Lozano T, Garcia-Vidal C, Fernandez-Ruiz M, Sanchez-Reus F, Castro-Mendez C, Guerrero-Lozano I, Soler-Palacin P, Aguado J, Martinez-Martinez L, Torre-Cisneros J, Nucci M, Spanish Fusariosis Study Grp |
| المساهمون: | Biomedicina, Biotecnología y Salud Pública, Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Red Española de Investigación en Patología Infecciosa, European Regional Development Fund, European Regional Development Fund (ERDF/FEDER) |
| المصدر: | Dipòsit Digital de la UB Universidad de Barcelona Zaguán. Repositorio Digital de la Universidad de Zaragoza instname EMERGING INFECTIOUS DISEASES r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau Fundacion Sancho el Sabio Fundazioa (FSS) Emerging Infectious Diseases Vol. 27, No. 1, January 2021 RODIN: Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz Universidad de Cádiz Emerging Infectious Diseases Repisalud Instituto de Salud Carlos III (ISCIII) Emerging Infectious Diseases, Vol 27, Iss 1, Pp 24-36 (2021) RODIN. Repositorio de Objetos de Docencia e Investigación de la Universidad de Cádiz Zaguán: Repositorio Digital de la Universidad de Zaragoza Universidad de Zaragoza r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante |
| بيانات النشر: | Centers for Disease Control and Prevention (CDC), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Antifungal Agents, Epidemiology, fusariosis, lcsh:Medicine, HEMATOLOGIC MALIGNANCIES, Fusarium, CME, health care economics and organizations, Neutropènia, musculoskeletal, neural, and ocular physiology, Mortality rate, Incidence (epidemiology), Observational Studies as Topic, Infectious Diseases, fungal infections, DISEASES, Synopsis, Microbiology (medical), Fusariosis, medicine.medical_specialty, Neutropenia, education, Invasive Fusariosis in Nonneutropenic Patients, Spain, 2000–2015, macromolecular substances, lcsh:Infectious and parasitic diseases, FUNGAL-INFECTIONS, Internal medicine, medicine, Mortalitat, Humans, lcsh:RC109-216, Risk factor, Mortality, Epidemiologia, Proportional hazards model, business.industry, lcsh:R, Retrospective cohort study, invasive fusariosis, MASS-SPECTROMETRY, medicine.disease, mortality, CELL TRANSPLANT RECIPIENTS, mycotic diseases, nervous system, Spain, incidence, fungi, business |
| الوصف: | Invasive fusariosis has a global increasing incidence and has emerged as a severe infection in nonneutropenic patients. Invasive fusariosis (IF) is associated with severe neutropenia in patients with concurrent hematologic conditions. We conducted a retrospective observational study to characterize the epidemiology of IF in 18 Spanish hospitals during 2000–2015. In that time, the frequency of IF in nonneutropenic patients increased from 0.08 cases per 100,000 admissions in 2000–2009 to 0.22 cases per 100,000 admissions in 2010–2015. Nonneutropenic IF patients often had nonhematologic conditions, such as chronic cardiac or lung disease, rheumatoid arthritis, history of solid organ transplantation, or localized fusariosis. The 90-day death rate among nonneutropenic patients (28.6%) and patients with resolved neutropenia (38.1%) was similar. However, the death rate among patients with persistent neutropenia (91.3%) was significantly higher. We used a multivariate Cox regression analysis to characterize risk factors for death: persistent neutropenia was the only risk factor for death, regardless of antifungal therapy. |
| وصف الملف: | application/pdf |
| تدمد: | 1080-6040 1080-6059 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::657e204349fe13eca7d029cf305fca5e http://hdl.handle.net/2445/173883 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....657e204349fe13eca7d029cf305fca5e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10806040 10806059 |
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