The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial
| العنوان: | The effect of vitamin D and magnesium supplementation on the mental health status of attention-deficit hyperactive children: a randomized controlled trial |
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| المؤلفون: | Jenna McVicar, Sheikh Mohammed Shriful Islam, Alireza Amanollahi, Naseh Pahlavani, Mostafa Hemamy, Gholamreza Askari, Mahsa Malekahmadi |
| المصدر: | BMC Pediatrics, Vol 21, Iss 1, Pp 1-8 (2021) BMC Pediatrics |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pediatrics, medicine.medical_specialty, Supplementation, Health Status, Placebo, RJ1-570, law.invention, 03 medical and health sciences, 0302 clinical medicine, Neurodevelopmental disorder, Randomized controlled trial, Double-Blind Method, law, Vitamin D and neurology, Medicine, Attention deficit hyperactivity disorder, Humans, Magnesium, 030212 general & internal medicine, Vitamin D, Child, business.industry, Strengths and Difficulties Questionnaire, medicine.disease, Mental health, Clinical trial, Attention Deficit Disorder with Hyperactivity, Pediatrics, Perinatology and Child Health, Dietary Supplements, Attention-deficit hyperactivity disorder, business, 030217 neurology & neurosurgery, Research Article |
| الوصف: | Background Attention-Deficit / Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder, characterized by varying severity in attention deficit and hyperactivity. Studies have shown deficiencies in the serum level of magnesium and vitamin D in people with ADHD. The aim of this study is to determine the effect of vitamin D and magnesium supplementation on mental health in children with ADHD. Methods We conducted a randomized, double blind, placebo-controlled clinical trial of 66 children with ADHD. Participants were randomly allocated to receive both vitamin D (50,000 IU/week) plus magnesium (6 mg/kg/day) supplements (n = 33) or placebos (n = 33) for 8-weeks. Strengths and difficulties questionnaire was used to evaluate children’s mental health at baseline and the end of the study. Results After eight weeks of intervention, the serum levels of 25-hydroxy-vitamin D3 and magnesium increased significantly in the intervention group compared with the control group. Also, children receiving vitamin D plus magnesium showed a significant reduction in emotional problems (p = 0.001), conduct problems (p = 0.002), peer problems (p = 0.001), prosocial score (p = 0.007), total difficulties (p = 0.001), externalizing score (p = 0.001), and internalizing score (p = 0.001) compared with children treated with the placebo. Conclusion Vitamin D (50,000 IU/week) and magnesium (6 mg/kg/day) co-supplementation for a duration of 8-weeks could improve the behavioral function and mental health of children with ADHD. However, further well-designed studies with a larger sample size are needed. Trial registration IRCT2016030326886N1. |
| اللغة: | English |
| تدمد: | 1471-2431 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64efdcc5ae1ae88b673da123e6a52fe5 https://doaj.org/article/73dab99a8db74470ab4ad7e9c96e87fd |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....64efdcc5ae1ae88b673da123e6a52fe5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712431 |
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