Mesial temporal lobe epilepsy: Clinical and neuropathologic findings of familial and sporadic forms
| العنوان: | Mesial temporal lobe epilepsy: Clinical and neuropathologic findings of familial and sporadic forms |
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| المؤلفون: | Marcelo Moraes Valença, João Pereira Leite, Luciano Neder, Fernando Cendes, Carlos Gilberto Carlotti, Luciana P. A. Andrade-Valença, Orfa Yineth Galvis-Alonso, João Alberto Assirati, Tonicarlo Rodrigues Velasco |
| المصدر: | Epilepsia. 49:1046-1054 |
| بيانات النشر: | Wiley, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, medicine.medical_treatment, Hippocampal formation, Hippocampus, Epilepsy, medicine, Humans, Ictal, Anterior temporal lobectomy, Neurons, Hippocampal sclerosis, Neuronal Plasticity, Sclerosis, Subiculum, Electroencephalography, Middle Aged, Anterior Temporal Lobectomy, medicine.disease, Magnetic Resonance Imaging, medicine.anatomical_structure, Epilepsy, Temporal Lobe, Neurology, Mossy Fibers, Hippocampal, Female, Fascia dentata, Neurology (clinical), Epileptic seizure, Atrophy, medicine.symptom, Psychology, Follow-Up Studies |
| الوصف: | Summary Purpose: To evaluate the clinical and hippocampal histological features of patients with mesial temporal lobe epilepsy (MTLE) in both familial (FMTLE) and sporadic (SMTLE) forms. Methods: Patients with FMTLE (n = 20) and SMTLE (n = 39) who underwent surgical treatment for refractory seizures were studied at the University of Sao Paulo School of Medicine at Ribeirao Preto. FMTLE was defined when at least two individuals in a family had clinical diagnosis of MTLE. Hippocampi from all patients were processed for Nissl/HE and Timm's stainings. Both groups were compared for clinical variables, hippocampal cell densities, and intensity of supragranular mossy fiber staining. Results: There were no significant differences between FMTLE and SMTLE groups in the following: age at the surgery, age of first usual epileptic seizure, history of initial precipitating injury (IPI), age of IPI, latent period, ictal and interictal video-EEG patterns, presence of hippocampal atrophy and signal changes at MRI, and postoperative outcome. In addition, no differences were found in cell densities in hippocampal cornu ammonis subfields (CA1, CA2, CA3, CA4), fascia dentata, polymorphic region, subiculum, prosubiculum, and presubiculum. However, patients with SMTLE had greater intensity of mossy fiber Timm's staining in the fascia dentata-inner molecular layer (p< 0.05). Discussion: Patients with intractable FMTLE present a clinical profile and most histological findings comparable to patients with SMTLE. Interestingly, mossy fiber sprouting was less pronounced in patients with FMTLE, suggesting that, when compared to SMTLE, patients with FMTLE respond differently to plastic changes plausibly induced by cell loss, neuronal deafferentation, or epileptic seizures. |
| تدمد: | 1528-1167 0013-9580 |
| DOI: | 10.1111/j.1528-1167.2008.01551.x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::641441d64aa415fc04eab0fdc7836fd0 https://doi.org/10.1111/j.1528-1167.2008.01551.x |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....641441d64aa415fc04eab0fdc7836fd0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15281167 00139580 |
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| DOI: | 10.1111/j.1528-1167.2008.01551.x |